{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:16:27Z","timestamp":1790363787872,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a widespread inflammatory skin disease with an early onset, characterized by pruritus, eczematous lesions and skin dryness. This chronic relapsing disease is believed to be primarily a result of a defective epidermal barrier function associated with genetic susceptibility, immune hyper\u2010responsiveness of the skin and environmental factors. Although the important role of abnormal immune reactivity in the pathogenesis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> is widely accepted, the role of regulatory T cells (T<jats:sub>regs<\/jats:sub>) remains elusive. We found that the T<jats:sub>reg<\/jats:sub> population is expanded in a mouse model of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, i.e. mice topically treated with vitamin D3 (VitD). Moreover, mice with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like symptoms exhibit increased inducible T\u2010cell costimulator (ICOS)\u2010, cytotoxic T\u2010lymphocyte antigen\u20104 (CTLA\u20104)\u2010 and Glycoprotein\u2010A repetitions predominant receptor (GARP)\u2010expressing T<jats:sub>regs<\/jats:sub> in skin\u2010draining lymph nodes. Importantly, the differentiation of T<jats:sub>regs<\/jats:sub> into thymus\u2010derived T<jats:sub>regs<\/jats:sub> is favoured in our mouse model of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Emigrated skin\u2010derived dendritic cells are required for T<jats:sub>reg<\/jats:sub> induction and Langerhans cells are responsible for the biased expansion of thymus\u2010derived T<jats:sub>regs<\/jats:sub>. Intriguingly, thymus\u2010derived T<jats:sub>regs<\/jats:sub> isolated from mice with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like symptoms exhibit a Th2 cytokine profile. Thus, <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> might favour the expansion of pathogenic T<jats:sub>regs<\/jats:sub> able to produce Th2 cytokines and to promote the disease instead of alleviating symptoms.<\/jats:p>","DOI":"10.1111\/jcmm.12806","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T05:32:48Z","timestamp":1456896768000},"page":"930-938","source":"Crossref","is-referenced-by-count":28,"title":["Atopic dermatitis induces the expansion of thymus\u2010derived regulatory T cells exhibiting a Th2\u2010like phenotype in mice"],"prefix":"10.1111","volume":"20","author":[{"given":"Verena","family":"Moosbrugger\u2010Martinz","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H.","family":"Tripp","sequence":"additional","affiliation":[{"name":"Department 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