{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:21:57Z","timestamp":1789611717048,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81270824"],"award-info":[{"award-number":["81270824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81570603"],"award-info":[{"award-number":["81570603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Pujiang Program","award":["15PJ1406700"],"award-info":[{"award-number":["15PJ1406700"]}]},{"name":"Shanghai Talents Development Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic kidney disease is associated with higher risk of cardiovascular complication and this interaction can lead to accelerated dysfunction in both organs. Renalase, a kidney\u2010derived cytokine, not only protects against various renal diseases but also exerts cardio\u2010protective effects. Here, we investigated the role of renalase in the progression of cardiorenal syndrome (\n                    <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>\n                    ) after subtotal nephrectomy. Sprague\u2013Dawley rats were randomly subjected to sham operation or subtotal (5\/6) nephrectomy (\n                    <jats:styled-content style=\"fixed-case\">STN<\/jats:styled-content>\n                    x). Two weeks after surgery, sham rats were intravenously injected with Hanks' balanced salt solution (sham), and STNx rats were randomly intravenously injected with adenovirus\u2010\u03b2\u2010gal (\n                    <jats:styled-content style=\"fixed-case\">STN<\/jats:styled-content>\n                    x+Ad\u2010\u03b2\u2010gal) or adenovirus\u2010renalase (\n                    <jats:styled-content style=\"fixed-case\">STN<\/jats:styled-content>\n                    x+Ad\u2010renalase) respectively. After 4 weeks of therapy, Ad\u2010renalase administration significantly restored plasma, kidney and heart renalase expression levels in\n                    <jats:styled-content style=\"fixed-case\">STN<\/jats:styled-content>\n                    x rats. We noticed that\n                    <jats:styled-content style=\"fixed-case\">STN<\/jats:styled-content>\n                    x rats receiving Ad\u2010renalase exhibited reduced proteinuria, glomerular hypertrophy and interstitial fibrosis after renal ablation compared with\n                    <jats:styled-content style=\"fixed-case\">STN<\/jats:styled-content>\n                    x rats receiving Ad\u2010\u03b2\u2010gal; these changes were associated with significant decreased expression of genes for fibrosis markers, proinflammatory cytokines and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase components. At the same time, systemic delivery of renalase attenuated hypertension, cardiomyocytes hypertrophy and cardiac interstitial fibrosis; prevented cardiac remodelling through inhibition of pro\u2010fibrotic genes expression and phosphorylation of extracellular signal\u2010regulated kinase (ERK)\u20101\/2. In summary, these results indicate that renalase protects against renal injury and cardiac remodelling after subtotal nephrectomy\n                    <jats:italic>via<\/jats:italic>\n                    inhibiting inflammation, oxidative stress and phosphorylation of\n                    <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>\n                    \u20101\/2. Renalase shows potential as a therapeutic target for the prevention and treatment of\n                    <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>\n                    in patients with chronic kidney disease.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12813","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T05:26:46Z","timestamp":1456723606000},"page":"1106-1117","source":"Crossref","is-referenced-by-count":47,"title":["Renalase attenuates hypertension, renal injury and cardiac remodelling in rats with subtotal nephrectomy"],"prefix":"10.1111","volume":"20","author":[{"given":"Jianyong","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of 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