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Any disturbance in this system causes proteins to accumulate, resulting in neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), Parkinson's disease, Huntington's disease and prion or polyglutamine diseases. Alzheimer's disease is currently one of the most common age\u2010related neurodegenerative diseases. However, its exact cause and pathogenesis are unknown. Currently approved medications for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> provide symptomatic relief; however, they fail to influence disease progression. Moreover, the components of the cellular quality control system represent an important focus for the development of targeted and potent therapies for managing <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. This review aims to evaluate whether existing evidence supports the hypothesis that <jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content> impairment causes the early pathogenesis of neurodegenerative disorders. The first part presents basic information about the <jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content> and its molecular components. The next part explains how the <jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content> is involved in neurodegenerative disorders. Finally, we emphasize how the <jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content> influences the management of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. This review may help in the design of future <jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content>\u2010related therapies for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.12817","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T11:55:29Z","timestamp":1459425329000},"page":"1392-1407","source":"Crossref","is-referenced-by-count":114,"title":["The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Kundlik","family":"Gadhave","sequence":"first","affiliation":[{"name":"Laboratory of Neurobiology Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER) Gauhati Medical College Guwahati Assam 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