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Ambient fine particulate matter (\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    ) is the key component for air pollution, and associated with significant mortality. The majority of the mortality following\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    exposure is related to cardiovascular diseases. However, the mechanisms for the adverse effects of\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    exposure on cardiovascular system remain largely unknown and under active investigation. Endothelial dysfunction or injury is considered one of the major factors that contribute to the development of cardiovascular diseases such as atherosclerosis and coronary heart disease. Endothelial progenitor cells (\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    s) play a critical role in maintaining the structural and functional integrity of vasculature. Particulate matter exposure significantly suppressed the number and function of\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    s in animals and humans. However, the mechanisms for the detrimental effects of\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    on\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    s remain to be fully defined. One of the important mechanisms might be related to increased level of reactive oxygen species (\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    ) and inflammation. Bone marrow (\n                    <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\n                    ) is a major source of\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    s. Thus, the number and function of\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    s could be intimately associated with the population and functional status of stem cells (\n                    <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\n                    s) in the\n                    <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\n                    . Bone marrow stem cells and other\n                    <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\n                    s have the potential for cardiovascular regeneration and repair. The present review is focused on summarizing the detrimental effects of\n                    <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                    exposure on\n                    <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>\n                    s and\n                    <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\n                    s, and potential mechanisms including\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    formation as well as clinical implications.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12822","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T07:50:29Z","timestamp":1458287429000},"page":"782-793","source":"Crossref","is-referenced-by-count":36,"title":["Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells"],"prefix":"10.1111","volume":"20","author":[{"given":"Yuqi","family":"Cui","sequence":"first","affiliation":[{"name":"Dorothy M. Davis Heart and Lung Research Institute Division of Cardiovascular Medicine The Ohio State University Wexner Medical Center Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Sun","sequence":"additional","affiliation":[{"name":"Dorothy M. Davis Heart and Lung Research Institute Division of Cardiovascular Medicine The Ohio State University Wexner Medical Center Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Dorothy M. 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