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Streptozotocin\u2010induced diabetic C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice were treated with\/without whole\u2010body <jats:styled-content style=\"fixed-case\">LDR<\/jats:styled-content> (12.5, 25, or 50 mGy) every 2 days. Twelve weeks after onset of diabetes, cardiomyopathy was diagnosed characterized by significant cardiac dysfunction, hypertrophy and histopathological abnormalities associated with increased oxidative stress and apoptosis, which was prevented by <jats:styled-content style=\"fixed-case\">LDR<\/jats:styled-content> (25 or 50 mGy only). Low\u2010dose radiation\u2010induced cardiac protection also associated with P53 inactivation, enhanced Nrf2 function and improved Akt activation. Next, for the mechanistic study, mouse primary cardiomyocytes were treated with high glucose (33 mmol\/l) for 24 hrs and during the last 15 hrs bovine serum albumin\u2010conjugated palmitate (62.5 \u03bcmol\/l) was added into the medium to mimic diabetes, and cells were treated with <jats:styled-content style=\"fixed-case\">LDR<\/jats:styled-content> (25 mGy) every 6 hrs during the whole process of <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\/Pal treatment. Data show that blocking Akt\/<jats:styled-content style=\"fixed-case\">MDM<\/jats:styled-content>2\/P53 or Akt\/Nrf2 pathways with small interfering <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> of akt, mdm2 and nrf2 not only prevented <jats:styled-content style=\"fixed-case\">LDR<\/jats:styled-content>\u2010induced anti\u2010apoptotic and anti\u2010oxidant effects but also prevented <jats:styled-content style=\"fixed-case\">LDR<\/jats:styled-content>\u2010induced suppression on cardiomyocyte hypertrophy and fibrosis against <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>\/Pal. Low\u2010dose radiation prevented diabetic cardiomyopathy by improving cardiac function and hypertrophic remodelling attributed to Akt\/<jats:styled-content style=\"fixed-case\">MDM<\/jats:styled-content>2\/P53\u2010mediated anti\u2010apoptotic and Akt\/Nrf2\u2010mediated anti\u2010oxidant pathways simultaneously.<\/jats:p>","DOI":"10.1111\/jcmm.12823","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T01:16:44Z","timestamp":1458350204000},"page":"1352-1366","source":"Crossref","is-referenced-by-count":33,"title":["Low\u2010dose radiation prevents type 1 diabetes\u2010induced cardiomyopathy <i>via<\/i> activation of <scp>AKT<\/scp> mediated anti\u2010apoptotic and anti\u2010oxidant effects"],"prefix":"10.1111","volume":"20","author":[{"given":"Fangfang","family":"Zhang","sequence":"first","affiliation":[{"name":"Chinese\u2010American Research Institute for Diabetic Complications Wenzhou Medical University Wenzhou China"},{"name":"Ruian Center of 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