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Benzimidazole and imidazopyridine compounds are a class of compounds with a variety of activities, including anti\u2010inflammatory, antioxidant and anti\u2010cancer. X22 is an imidazopyridine derivative we synthesized and evaluated previously for anti\u2010inflammatory activity in lipopolysaccharide\u2010stimulated macrophages. However, its ability to alleviate obesity\u2010induced heart injury\n                    <jats:italic>via<\/jats:italic>\n                    its anti\u2010inflammatory actions was unclear. This study was designed to evaluate the cardioprotective effects of X22 using cell culture studies and a high\u2010fat diet rat model. We observed that palmitic acid treatment in cardiac\u2010derived H9c2 cells induced a significant increase in reactive oxygen species, inflammation, apoptosis, fibrosis and hypertrophy. All of these changes were inhibited by treatment with X22. Furthermore, oral administration of X22 suppressed high\u2010fat diet\u2010induced oxidative stress, inflammation, apoptosis, hypertrophy and fibrosis in rat heart tissues and decreased serum lipid concentration. We also found that the anti\u2010inflammatory and anti\u2010oxidative actions of X22 were associated with Nrf2 activation and nuclear factor\u2010kappaB (\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\u03baB) inhibition, respectively, both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The results of this study indicate that X22 may be a promising cardioprotective agent and that Nrf2 and\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\u03baB may be important therapeutic targets for obesity\u2010related complications.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12832","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T12:52:56Z","timestamp":1459169576000},"page":"1427-1442","source":"Crossref","is-referenced-by-count":35,"title":["Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity"],"prefix":"10.1111","volume":"20","author":[{"given":"Yuanyuan","family":"Qian","sequence":"first","affiliation":[{"name":"Chemical Biology Research Center School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou Zhejiang 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