{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T14:10:21Z","timestamp":1714054221576},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple studies demonstrated that anti\u2010human T lymphocyte immune globulins (<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) can decrease the incidence of acute and chronic graft rejection in cell or organ transplants. However, further in\u2010depth study indicates that different subgroups may benefit from either different regimes or alteration of them. Studies among renal transplant patients indicate that low immunological risk patients may not gain the same amount of benefit and thus tilt the risk <jats:italic>versus<\/jats:italic> benefit consideration. This may hold true for low immunological risk patients receiving other organ transplants and would be worth further investigation. The recovery time of T cells and <jats:styled-content style=\"fixed-case\">natural killer (NK)<\/jats:styled-content> cells also bears consideration and the impact that it has on the severity and incidence of opportunistic infections closely correlated with the dosage of <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>. The use of lower doses of <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> in combination with other induction medications may offer a solution. The finding that <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> may lose efficacy in cases of multiple transplants or re\u2010transplants in the case of heart transplants may hold true for other transplantations. This may lead to reconsideration of which induction therapies would be most beneficial in the clinical setting. These studies on <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> done on different patient groups will naturally not be applicable to all, but the evidence accrued from them as a whole may offer us new and different perspectives on how to approach and potentially solve the clinical question of how to best reduce the mortality associated with chronic host\u2010<jats:italic>versus<\/jats:italic>\u2010graft disease.<\/jats:p>","DOI":"10.1111\/jcmm.12860","type":"journal-article","created":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T05:07:03Z","timestamp":1460783223000},"page":"1796-1799","source":"Crossref","is-referenced-by-count":4,"title":["Effects of anti\u2010human T lymphocyte immune globulins in patients: new or old"],"prefix":"10.1111","volume":"20","author":[{"given":"Diane C.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Wenzhou Medical University Wenzhou 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