{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:30:04Z","timestamp":1790785804483,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972642"],"award-info":[{"award-number":["30972642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972528"],"award-info":[{"award-number":["30972528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172749"],"award-info":[{"award-number":["81172749"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>\n \n The nuclear factor erythroid\u2010derived two\u2010like 2\u2010antioxidant response element (Nrf2\u2010\n ARE<\/jats:styled-content>\n ) pathway and its downstream antioxidant enzyme heme oxygenase\u20101 (\n HMOX<\/jats:styled-content>\n 1 or\n HO<\/jats:styled-content>\n \u20101) play essential roles in H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n \u2010induced oxidative damage in human melanocytes. However, the link between\n Nrf2<\/jats:italic>\n promoter polymorphisms and susceptibility to oxidative stress\u2010related diseases such as vitiligo is unknown. This study evaluated the association of the\n Nrf2<\/jats:italic>\n and\n \n HO<\/jats:styled-content>\n \u20101\n <\/jats:italic>\n genes polymorphisms with vitiligo susceptibility. In this case\u2013control study of 1136 Han Chinese vitiligo patients and 1200 controls,\n Nrf2<\/jats:italic>\n (rs35652124 and rs6721961) and\n \n HO<\/jats:styled-content>\n \u20101\n <\/jats:italic>\n (rs2071746) genes were genotyped by\n PCR<\/jats:styled-content>\n \u2010restriction fragment length polymorphism analysis. Overall, a significantly decreased risk of vitiligo was found to be associated with\n Nrf2<\/jats:italic>\n rs35652124\n CC<\/jats:styled-content>\n and combined (\n CT<\/jats:styled-content>\n +\n CC<\/jats:styled-content>\n ) genotypes [odds ratio (\n OR<\/jats:styled-content>\n ) 0.64, 95% confidence interval (\n CI<\/jats:styled-content>\n ) 0.50\u20130.83 and\n OR<\/jats:styled-content>\n , 0.84, 95%\n CI<\/jats:styled-content>\n 0.71\u20130.99, respectively], as well as among subgroups: female, onset age \u226420 and never smoker. We subsequently found that\n Nrf2<\/jats:italic>\n rs35652124 C allele had higher transcriptional activity in the luciferase reporter assay compared with\n Nrf2<\/jats:italic>\n rs35652124 T allele. Furthermore, we investigated serum\n HO<\/jats:styled-content>\n \u20101 activity was associated with the rs35652124\n CT<\/jats:styled-content>\n +\n CC<\/jats:styled-content>\n genotype and lower in patients than in controls (\n P<\/jats:italic>\n = 0.024). Logistic regression analysis showed a dose\u2013response relationship between lower vitiligo risk and increased\n HO<\/jats:styled-content>\n \u20101 activity in rs35652124\n CT<\/jats:styled-content>\n +\n CC<\/jats:styled-content>\n genotype carriers (\n P<\/jats:italic>\n trend<\/jats:sub>\n < 0.05). These findings indicate that the C allele of rs35652124 located in the promoter region of\n Nrf2<\/jats:italic>\n gene is associated with protective effect on vitiligo in a Han Chinese population.\n <\/jats:p>","DOI":"10.1111\/jcmm.12874","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T03:02:17Z","timestamp":1464145337000},"page":"1840-1850","source":"Crossref","is-referenced-by-count":36,"title":["Genetic polymorphism of the\n Nrf2<\/i>\n promoter region is associated with vitiligo risk in Han Chinese populations"],"prefix":"10.1111","volume":"20","author":[{"given":"Pu","family":"Song","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an 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