{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:02:18Z","timestamp":1794261738391,"version":"4.9.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["14\/23703\u20100"],"award-info":[{"award-number":["14\/23703\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["10\/50048\u20101"],"award-info":[{"award-number":["10\/50048\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac endoplasmic reticulum (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) stress through accumulation of misfolded proteins plays a pivotal role in cardiovascular diseases. In an attempt to reestablish <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> homoeostasis, the unfolded protein response (<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>) is activated. However, if <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress persists, sustained <jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content> activation leads to apoptosis. There is no available therapy for <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress relief. Considering that aerobic exercise training (<jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content>) attenuates oxidative stress, mitochondrial dysfunction and calcium imbalance, it may be a potential strategy to reestablish cardiac <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> homoeostasis. We test the hypothesis that <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> would attenuate impaired cardiac <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress after myocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>). Wistar rats underwent to either <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> or sham surgeries. Four weeks later, rats underwent to 8 weeks of moderate\u2010intensity <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content>. Myocardial infarction rats displayed cardiac dysfunction and lung oedema, suggesting heart failure. Cardiac dysfunction in <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> rats was paralleled by increased protein levels of <jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content> markers (GRP78, <jats:styled-content style=\"fixed-case\">DERLIN<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>), accumulation of misfolded and polyubiquitinated proteins, and reduced chymotrypsin\u2010like proteasome activity. These results suggest an impaired cardiac protein quality control. Aerobic exercise training improved exercise capacity and cardiac function of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> animals. Interestingly, <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> blunted <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress by reducing protein levels of <jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content> markers, and accumulation of both misfolded and polyubiquinated proteins, which was associated with restored proteasome activity. Taken together, our study provide evidence for <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> attenuation of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress through the reestablishment of cardiac protein quality control, which contributes to better cardiac function in post\u2010<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> heart failure rats. These results reinforce the importance of <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> as primary non\u2010pharmacological therapy to cardiovascular disease.<\/jats:p>","DOI":"10.1111\/jcmm.12894","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T09:31:18Z","timestamp":1466069478000},"page":"2208-2212","source":"Crossref","is-referenced-by-count":53,"title":["Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats"],"prefix":"10.1111","volume":"20","author":[{"given":"Luiz H. M.","family":"Bozi","sequence":"first","affiliation":[{"name":"School of Physical Education and Sport University of Sao Paulo Sao Paulo Brazil"},{"name":"Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo R.","family":"Jannig","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natale","family":"Rolim","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging Norwegian University of Science and Technology \u2010 NTNU Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa A.","family":"Voltarelli","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo M. M.","family":"Dourado","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Biomedical Science University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Wisl\u00f8ff","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging Norwegian University of Science and Technology \u2010 NTNU Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C.","family":"Brum","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00002-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052764"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00188.2006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033175"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00424.2007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152907781745260"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3751"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(04)18"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173948"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00760.2012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-008-0967-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1802-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180cc25c7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137836.95625.D4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.203901"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.10.032"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0805-766"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200507057"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12894","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12894","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12894","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:45:49Z","timestamp":1695483949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jcmm.12894"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12894","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}