{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:51:15Z","timestamp":1772999475033,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heilongjiang Provincial Education Office Scientific & Technologic Research Project","award":["12541914"],"award-info":[{"award-number":["12541914"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatocellular carcinoma is a complex polygenic disease. Despite the huge advances in genetic epidemiology, it still remains a challenge to unveil the genetic architecture of hepatocellular carcinoma. We, therefore, decided to meta\u2010analytically assess the association of six non\u2010synonymous coding variants from <jats:italic><jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic> genes with hepatocellular carcinoma risk by pooling the results of 20 English articles. This meta\u2010analysis was conducted according to the <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> statement, and data collection was independently completed in duplicate. In overall analyses, the minor alleles of four variants, Arg280His (odds ratio, 95% confidence interval, <jats:italic>P<\/jats:italic>: 1.37, 1.13\u20131.66, 0.001), Thr241Met (1.93, 1.17\u20133.20, 0.011), Asp312Asn (1.22, 1.08\u20131.38, 0.001) and Lys751Gln (1.42, 1.02\u20131.97, 0.038), were associated with the significant risk for hepatocellular carcinoma. There were low probabilities of publication bias for all variants. Subgroup analyses revealed significant association of <jats:italic><jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1<\/jats:italic> gene Arg399Gln with hepatocellular carcinoma in Chinese especially from south China (odds ratio, 95% confidence interval, <jats:italic>P<\/jats:italic>: 1.57, 1.16\u20132.14, 0.004), in larger studies (1.48, 1.11\u20131.98, 0.007) and in studies with population\u2010based controls (1.33, 1.06\u20131.68, 0.016). Taken together, our findings demonstrated that <jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic> gene Asp312Asn and <jats:italic><jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>1<\/jats:italic> gene Arg399Gln might be candidate susceptibility loci for hepatocellular carcinoma. Considering the ubiquity of genetic heterogeneity, further validation in a broad range of ethnic populations is warranted.<\/jats:p>","DOI":"10.1111\/jcmm.12896","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T10:55:03Z","timestamp":1466074503000},"page":"2056-2063","source":"Crossref","is-referenced-by-count":9,"title":["The association of six non\u2010synonymous variants in three <scp>DNA<\/scp> repair genes with hepatocellular carcinoma risk: a meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Yan\u2010Hui","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Qiqihar City Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology Qiqihar Medical University Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai\u2010Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Intervention Therapy Department The First Hospital of Qiqihar City Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan\u2010Na","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Qiqihar City Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Mei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Qiqihar City Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man\u2010Ru","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Qiqihar City Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Central Laboratory Qiqihar Medical University Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology Qiqihar Medical University Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Zhu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Physiology Qiqihar Medical University Qiqihar Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.10.028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00070-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9082636"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_7_9_1","first-page":"9931","article-title":"Effect of APE1 and XRCC1 gene polymorphism on susceptibility to hepatocellular carcinoma and sensitivity to cisplatin","volume":"8","author":"Yang Z","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_10_1","first-page":"6231","article-title":"Interaction of DNA repair gene polymorphisms and aflatoxin B1 in the risk of hepatocellular carcinoma","volume":"7","author":"Yao JG","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4238\/2014.May.16.5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1451-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2409-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328359a775"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.02.025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2012.1646"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2192-6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.581"},{"key":"e_1_2_7_19_1","first-page":"2285","article-title":"Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk","volume":"59","author":"Han X","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.9.4423"},{"key":"e_1_2_7_21_1","first-page":"2947","article-title":"Polymorphism of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population","volume":"12","author":"Pan HZ","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-400"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-009-0035-3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2008.03.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.08.006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2006.06.004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0161"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi191"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-010-4062-9"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)00098-B"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12896","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:45:27Z","timestamp":1695483927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jcmm.12896"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12896","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}