{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:50:03Z","timestamp":1782208203056,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00DK093788"],"award-info":[{"award-number":["R00DK093788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bromodomain\u2010containing protein 7 (\n                    <jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>\n                    7) is a member of bromodomain\u2010containing protein family and its function has been implicated in several diseases. We have previously shown that\n                    <jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>\n                    7 plays a role in metabolic processes. However, the effect of\n                    <jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>\n                    7 deficiency in glucose metabolism and its role in\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    have not been fully revealed. Here, we report the essential role of\n                    <jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>\n                    7 during embryo development. Mice homozygous for\n                    <jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>\n                    7 led to embryonic lethality at mid\u2010gestation. Homozygous\n                    <jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>\n                    7 knockout (\n                    <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>\n                    ) mice showed retardation in development, and eventually all\n                    <jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>\n                    7\n                    <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>\n                    embryos died\n                    <jats:italic>in utero<\/jats:italic>\n                    prior to E16.5. Partial knockdown of\n                    <jats:italic>Brd7<\/jats:italic>\n                    gene displayed mild changes in glucose metabolism.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.12907","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T03:26:06Z","timestamp":1469157966000},"page":"1561-1570","source":"Crossref","is-referenced-by-count":17,"title":["The role of\n                    <scp>BRD<\/scp>\n                    7 in embryo development and glucose metabolism"],"prefix":"10.1111","volume":"20","author":[{"given":"Yoo","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology Boston Children's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Andr\u00e9s Salazar Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Boston Children's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Herrema","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Boston Children's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuncay","family":"Delibasi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine, Kastamonu Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Boston Children's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210604"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07607.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63049-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210852"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.1.764"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09730"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq184"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.10.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/rns.2011.018"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-007-9466-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5033"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2038"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009559107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2089"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.04.006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.02.016"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2099"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.2.152"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103160"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204363"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209871"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702969104"}],"container-title":["Journal 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