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Previous studies noted fewer <jats:styled-content style=\"fixed-case\">RGC<\/jats:styled-content>s after immunization with ocular antigens at 28 days. It is known that changes in extracellular matrix (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) components conduct retina and optic nerve degeneration. Here, we focused on the remodelling of tenascin\u2010C and phosphacan\/receptor protein tyrosine phosphatase \u03b2\/\u03b6 in an autoimmune glaucoma model. Rats were immunized with optic nerve homogenate (<jats:styled-content style=\"fixed-case\">ONA<\/jats:styled-content>) or S100B protein (S100). Controls received sodium chloride (Co). After 14 days, no changes in <jats:styled-content style=\"fixed-case\">RGC<\/jats:styled-content> number were noted in all groups. An increase in <jats:italic><jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression was observed in the S100 group, whereas no alterations were noted <jats:italic>via<\/jats:italic> immunohistochemistry in both groups. Extracellular matrix remodelling was analyzed after 3, 7, 14 and 28 days. Tenascin\u2010C and 473<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> immunoreactivity in retinae and optic nerves was unaltered in both immunized groups at 3 days. At 7 days, tenascin\u2010C staining increased in both tissues in the <jats:styled-content style=\"fixed-case\">ONA<\/jats:styled-content> group. Also, in the optic nerves of the S100 group, an intense tenascin\u2010C staining could be shown. In the retina, an increased tenascin\u2010C expression was also observed in <jats:styled-content style=\"fixed-case\">ONA<\/jats:styled-content> animals <jats:italic>via<\/jats:italic> Western blot. 473<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> immunoreactivity was elevated in the <jats:styled-content style=\"fixed-case\">ONA<\/jats:styled-content> group in both tissues and in the S100 optic nerves at 7 days. At 14 days, tenascin\u2010C and 473<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> immunoreactivity was up\u2010regulated in the <jats:styled-content style=\"fixed-case\">ONA<\/jats:styled-content> retinae, whereas phosphacan expression was up\u2010regulated in both groups. We conclude that remodelling of tenascin\u2010C and phosphacan occurred shortly after immunization, already before <jats:styled-content style=\"fixed-case\">RGC<\/jats:styled-content> loss. We assume that both <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> molecules represent early indicators of neurodegeneration.<\/jats:p>","DOI":"10.1111\/jcmm.12909","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T06:59:11Z","timestamp":1467615551000},"page":"2122-2137","source":"Crossref","is-referenced-by-count":39,"title":["Early remodelling of the extracellular matrix proteins tenascin\u2010C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model"],"prefix":"10.1111","volume":"20","author":[{"given":"Sabrina","family":"Reinehr","sequence":"first","affiliation":[{"name":"Experimental Eye Research Institute University Eye Hospital Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Cell Morphology and Molecular Neurobiology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Wiemann","sequence":"additional","affiliation":[{"name":"Department of Cell Morphology and Molecular Neurobiology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gesa","family":"Stute","sequence":"additional","affiliation":[{"name":"Experimental Eye Research Institute University Eye Hospital Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Kuehn","sequence":"additional","affiliation":[{"name":"Experimental Eye Research Institute University Eye Hospital Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Woestmann","sequence":"additional","affiliation":[{"name":"Department of Cell Morphology and Molecular Neurobiology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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