{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:14:20Z","timestamp":1695622460736},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF\u20102012R1A5A2A42671316","2014R1A2A1A11049526"],"award-info":[{"award-number":["NRF\u20102012R1A5A2A42671316","2014R1A2A1A11049526"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug repositioning is used to discover drug candidates to treat human diseases, through the application of drugs or compounds that are approved for the treatment of other diseases. This method can significantly reduce the time required and cost of discovering new drug candidates for human diseases. Previous studies have reported pro\u2010inflammatory responses of endothelial cells to the release of polyphosphate (PolyP). In this study, we examined the anti\u2010inflammatory responses and mechanisms of methylthiouracil (<jats:styled-content style=\"fixed-case\">MTU<\/jats:styled-content>), which is an antithyroid drug, and its effects on PolyP\u2010induced septic activities in human umbilical vein endothelial cells (<jats:styled-content style=\"fixed-case\">HUVEC<\/jats:styled-content>s) and mice. The survival rates, septic biomarker levels, behaviour of human neutrophils and vascular permeability were determined in PolyP\u2010activated <jats:styled-content style=\"fixed-case\">HUVEC<\/jats:styled-content>s and mice. <jats:styled-content style=\"fixed-case\">MTU<\/jats:styled-content> suppressed the PolyP\u2010mediated vascular barrier permeability, up\u2010regulation of inflammatory biomarkers, adhesion\/migration of leucocytes, and activation and\/or production of nuclear factor\u2010\u03baB, tumour necrosis factor\u2010\u03b1 and interleukin\u20106. Furthermore, <jats:styled-content style=\"fixed-case\">MTU<\/jats:styled-content> demonstrated protective effects on PolyP\u2010mediated lethal death and the levels of the related septic biomarkers. Therefore, these results indicated the therapeutic potential of <jats:styled-content style=\"fixed-case\">MTU<\/jats:styled-content> on various systemic inflammatory diseases, such as sepsis or septic shock.<\/jats:p>","DOI":"10.1111\/jcmm.12925","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T16:15:29Z","timestamp":1468599329000},"page":"2333-2340","source":"Crossref","is-referenced-by-count":2,"title":["Suppressive effects of methylthiouracil on polyphosphate\u2010mediated vascular inflammatory responses"],"prefix":"10.1111","volume":"20","author":[{"given":"Gahee","family":"Min","sequence":"first","affiliation":[{"name":"College of Pharmacy CMRI Research Institute of Pharmaceutical Sciences BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team Kyungpook National University Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae\u2010Kwang","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology College of Korean Medicine Daegu Haany University Gyeongsan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongdo","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Pharmacy CMRI Research Institute of Pharmaceutical Sciences BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team Kyungpook National University Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon\u2010Chang","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine CMRI School of Medicine Kyungpook National University Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Sup","family":"Bae","sequence":"additional","affiliation":[{"name":"College of Pharmacy CMRI Research Institute of Pharmaceutical Sciences BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team Kyungpook National University Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"172","article-title":"The cost of new drug discovery and development","volume":"4","author":"Dickson M","year":"2004","journal-title":"Discov Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.81870"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1900"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.5818"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(08)60385-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303468200"},{"key":"e_1_2_6_8_1","first-page":"1180","article-title":"Inorganic polyphosphate and specific induction of apoptosis in human plasma cells","volume":"91","author":"Hernandez\u2010Ruiz L","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04671.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0613-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-015-0906-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2033OC"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.11.038"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.10.044"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0501-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0410-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199811000-00038"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2013.46.11.056"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-360701"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0171-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000021127.83364.7D"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0330-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2012.45.3.200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04671.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.11.005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.727"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00022.2008"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-0901-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100589"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1334.h81602001334_1334_1339"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0075OC"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.4122007re8"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1487"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000021902.33129.69"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2003.10.004"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000072971.88704.CB"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.3.314"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0498"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116778"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00054.2009"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)01134-9"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.12925","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.12925","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.12925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:57:51Z","timestamp":1695571071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.12925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/jcmm.12925"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.12925","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,15]]}}}