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Endoplasmic reticulum (ER) stress\u2010induced apoptosis plays a key role in diabetic cardiomyopathy (DCM). However, the molecular mechanism of hyperglycaemia\u2010induced myocardial apoptosis is still unclear. We intended to determine the role of BRD7 in high glucose (HG)\u2010induced apoptosis of cardiomyocytes. <jats:italic>In vivo<\/jats:italic>, we established a type 1 diabetic rat model by injecting a high\u2010dose streptozotocin (STZ), and lentivirus\u2010mediated short hairpin RNA (shRNA) was used to inhibit BRD7 expression. Rats with DCM exhibited severe myocardial remodelling, fibrosis, left ventricular dysfunction and myocardial apoptosis. The expression of BRD7 was up\u2010regulated in the heart of diabetic rats, and inhibition of BRD7 had beneficial effects against diabetes\u2010induced heart damage. <jats:italic>In vitro<\/jats:italic>, H9c2 cardiomyoblasts was used to investigate the mechanism of BRD7 in HG\u2010induced apoptosis. Treating H9c2 cardiomyoblasts with HG elevated the level of BRD7 <jats:italic>via<\/jats:italic> activation of extracellular signal\u2010regulated kinase 1\/2 (ERK1\/2) and increased ER stress\u2010induced apoptosis by detecting spliced\/active X\u2010box binding protein 1 (XBP\u20101s) and C\/EBP homologous protein (CHOP). Furthermore, down\u2010regulation of BRD7 attenuated HG\u2010induced expression of CHOP <jats:italic>via<\/jats:italic> inhibiting nuclear translocation of XBP\u20101s without affecting the total expression of XBP\u20101s. In conclusion, inhibition of BRD7 appeared to protect against hyperglycaemia\u2010induced cardiomyocyte apoptosis by inhibiting ER stress signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.13041","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T07:16:44Z","timestamp":1481613404000},"page":"1094-1105","source":"Crossref","is-referenced-by-count":35,"title":["BRD7 mediates hyperglycaemia\u2010induced myocardial apoptosis <i>via<\/i> endoplasmic reticulum stress signalling pathway"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiao\u2010meng","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010cui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Qilu Hospital of Shandong University (Qingdao) Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang\u2010juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Jinan Central Hospital Affiliated to Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Mao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010ming","family":"Ge","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080500"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(72)90595-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9313-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.10.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00278.2006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.12.1123"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.2337\/diab.34.9.876","article-title":"A functional and ultrastructural analysis of experimental diabetic rat myocardium . 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