{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:51:42Z","timestamp":1790340702968,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,12]],"date-time":"2017-03-12T00:00:00Z","timestamp":1489276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270202"],"award-info":[{"award-number":["81270202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91339113"],"award-info":[{"award-number":["91339113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI103618"],"award-info":[{"award-number":["AI103618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and regulated by various signalling pathways. Recently, we observed that mouse embryonic fibroblasts from CD38 knockout mice were significantly resistant to oxidative stress such as H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced injury and hypoxia\/reoxygenation\u2010induced injury. In addition, we also found that CD38 knockout mice protected heart from ischaemia reperfusion injury through activating SIRT1\/FOXOs\u2010mediated antioxidative stress pathway. However, the role of CD38 in cardiac hypertrophy is not explored. Here, we investigated the roles and mechanisms of CD38 in angiotensin II (Ang\u2010II)\u2010induced cardiac hypertrophy. Following 14 days of Ang\u2010II infusion with osmotic mini\u2010pumps, a comparable hypertension was generated in both of CD38 knockout and wild\u2010type mice. However, the cardiac hypertrophy and fibrosis were much more severe in wild\u2010type mice compared with CD38 knockout mice. Consistently, RNAi\u2010induced knockdown of CD38 decreased the gene expressions of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) and reactive oxygen species generation in Ang\u2010II\u2010stimulated H9c2 cells. In addition, the expression of SIRT3 was elevated in CD38 knockdown H9c2 cells, in which SIRT3 may further activate the FOXO3 antioxidant pathway. The intracellular Ca<jats:sup>2+<\/jats:sup> release induced by Ang\u2010II markedly decreased in CD38 knockdown H9c2 cells, which might be associated with the decrease of nuclear translocation of NFATc4 and inhibition of ERK\/AKT phosphorylation. We concluded that CD38 plays an essential role in cardiac hypertrophy probably <jats:italic>via<\/jats:italic> inhibition of SIRT3 expression and activation of Ca<jats:sup>2+<\/jats:sup>\u2010NFAT signalling pathway. Thus, CD38 may be a novel target for treating cardiac hypertrophy.<\/jats:p>","DOI":"10.1111\/jcmm.13076","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T15:16:19Z","timestamp":1489504579000},"page":"1492-1502","source":"Crossref","is-referenced-by-count":87,"title":["CD38 promotes angiotensin II\u2010induced cardiac hypertrophy"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiao\u2010Hui","family":"Guan","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Fei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Bin","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Ju","family":"Ji","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingui","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science Shock\/Trauma Research Center School of Medicine University of Missouri Kansas City Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4257-207X","authenticated-orcid":false,"given":"Hong\u2010Bo","family":"Xin","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.11.036"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn156"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.144.7.2811"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1588"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.07.040"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235624"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.05.042"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.1526"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.759305"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2011.76.010629"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1467506"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00053.2015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2004.11.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.077271"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7410257"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81573-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.049767"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068936"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00372.2004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0749com"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.01.021"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1324"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4179"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787185788"},{"key":"e_1_2_8_27_1","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a\u2010dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan NR","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.1999.00106.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004275200"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000364995"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5720758"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.2111"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.022"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq250"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.11.015"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.08.066"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq376"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2961"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01903.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.164558"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.8.2799-2809.2002"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204572200"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.1.117"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00048.2011"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9720-x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411787200"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.823799"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2007.00018.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01124.2005"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.220038"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.08.005"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000109415.17511.18"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149125"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500528200"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422220"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T15:22:22Z","timestamp":1696173742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,12]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jcmm.13076"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13076","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,12]]}}}