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Studies in rodent models suggest that <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content> therapy may confer therapeutic benefits in patients with non\u2010ischaemic dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>). We sought to determine the safety and efficacy of allogeneic <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content> in a large animal (canine) model of spontaneous <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>. Canine CDCs (cCDCs) were grown from a donor dog heart. Similar to human <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">cCDC<\/jats:styled-content>s express <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>105 and are slightly positive for c\u2010kit and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>90. Thirty million of allogeneic <jats:styled-content style=\"fixed-case\">cCDC<\/jats:styled-content>s was infused into the coronary vessels of Doberman pinscher dogs with spontaneous DCM. Adverse events were closely monitored, and cardiac functions were measured by echocardiography. No adverse events occurred during and after cell infusion. Histology on dog hearts (after natural death) revealed no sign of immune rejection from the transplanted cells.<\/jats:p>","DOI":"10.1111\/jcmm.13077","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T08:43:21Z","timestamp":1489567401000},"page":"1503-1512","source":"Crossref","is-referenced-by-count":31,"title":["Intracoronary allogeneic cardiosphere\u2010derived stem cells are safe for use in dogs with dilated cardiomyopathy"],"prefix":"10.1111","volume":"21","author":[{"given":"Michael Taylor","family":"Hensley","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University Raleigh NC 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