{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:11:45Z","timestamp":1780593105561,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81570732"],"award-info":[{"award-number":["No.81570732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Saitohin (<jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>) Q7R polymorphism has been reported to influence the individual's susceptibility to Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>); however, conclusions remain controversial. Therefore, we performed this meta\u2010analysis to explore the association between <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> Q7R polymorphism and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> risk. Systematic literature searches were performed in the PubMed, Embase, Cochrane Library and Web of Science for studies published before 31 August 2016. Pooled odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were calculated to assess the strength of the association using a fixed\u2010 or random\u2010effects model. Subgroup analyses, Galbraith plot and sensitivity analyses were also performed. All statistical analyses were performed with <jats:styled-content style=\"fixed-case\">STATA<\/jats:styled-content> Version 12.0. A total of 19 case\u2013control studies from 17 publications with 4387 cases and 3972 controls were included in our meta\u2010analysis. The results showed that the Q7R polymorphism was significantly associated with an increased risk of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in a recessive model (<jats:styled-content style=\"fixed-case\">RR <\/jats:styled-content><jats:italic>versus <\/jats:italic><jats:styled-content style=\"fixed-case\">QQ<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">QR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content>\u00a0=\u00a01.27, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.01\u20131.60, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.040). After excluding the four studies not carried out in caucasians, the overall association was unchanged in all comparison models. Further subgroup analyses stratified by the time of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> onset, and the quality of included studies provided statistical evidence of significant increased risk of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RR <\/jats:styled-content><jats:italic>versus <\/jats:italic><jats:styled-content style=\"fixed-case\">QQ<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">QR<\/jats:styled-content> model only in late\u2010onset subjects (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.56, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.07\u20132.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021) and in studies with high quality (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.37, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.01\u20131.86, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). This meta\u2010analysis suggests that the <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> genotype in saitohin Q7R polymorphism may be a human\u2010specific risk factor for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, especially among late\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> subjects and caucasian populations.<\/jats:p>","DOI":"10.1111\/jcmm.13079","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T06:56:41Z","timestamp":1487314601000},"page":"1448-1456","source":"Crossref","is-referenced-by-count":4,"title":["Saitohin Q7R polymorphism is associated with late\u2010onset Alzheimer's disease susceptibility among caucasian populations: a meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Rong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjue","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2494"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112194599"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2590-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2004.02320.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00788-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00670-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00635-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200401190-00034"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125693.59817.31"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086428"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-2-13"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091044"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.02.021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-008-1014-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0400-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr025"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06159"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10384"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10362"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.3.362"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071000"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506116200"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(86)90033-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9589-0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00955.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.04.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl029"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.11.013"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-8-48"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.12.007"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls187"},{"key":"e_1_2_8_36_1","first-page":"300","article-title":"Differences between early and late onset Alzheimer's disease","volume":"2","author":"Panegyres PK","year":"2013","journal-title":"Am J Neurodegener Dis"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.07.013"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020334"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T15:22:32Z","timestamp":1696173752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jcmm.13079"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13079","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}