{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:42:54Z","timestamp":1740145374197,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/15\/52\/31598"],"award-info":[{"award-number":["PG\/15\/52\/31598"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Whether oxygen should be administered acutely during ST\u2010segment elevation myocardial infarction is debated. Despite this controversy, the possible influence of supplementary oxygen on animal models of ischaemia\u2013reperfusion injury or cardioprotection is rarely considered. We used an <jats:italic>in vivo<\/jats:italic> mouse model of ischaemia and reperfusion to investigate the effect of ventilation with room air <jats:italic>versus<\/jats:italic> 100% oxygen. The coronary artery of anaesthetized mice was occluded for 40 min. followed by 2\u2010hrs reperfusion. Infarct size was measured by tetrazolium staining and expressed as a percentage of area at risk, determined using Evan's blue. Unexpectedly, infarct size in mice ventilated with 100% oxygen was significantly smaller than in those ventilated with room air (33 \u00b1 5% <jats:italic>versus<\/jats:italic> 46 \u00b1 3%; <jats:italic>n<\/jats:italic> = 6; <jats:italic>P<\/jats:italic> &lt; 0.01). We tested a standard protocol of 3 \u00d7 5 min. cycles of remote ischaemic preconditioning (RIPC) and found this was unable to protect mice ventilated with 100% oxygen. RIPC protocols using 2.5\u2010 or 10\u2010min. occlusion were similarly ineffective in mice ventilated with oxygen. Similar disparate results were obtained with direct cardiac ischaemic preconditioning. In contrast, pharmacological protection using bradykinin administered at reperfusion was effective even in mice ventilated with 100% oxygen, reducing infarct size from 33 \u00b1 5% to 21 \u00b1 3% (<jats:italic>n<\/jats:italic> = 4\u20136; <jats:italic>P<\/jats:italic> &lt; 0.01). Laser speckle contrast imaging of blood flow and direct pO<jats:sub>2<\/jats:sub> measurements were made in the hindlimb, but these measurements did not correlate with protection. In conclusion, ventilation protocol can have a major influence on infarct size and ischaemic preconditioning protocols in mice.<\/jats:p>","DOI":"10.1111\/jcmm.13164","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:26:08Z","timestamp":1491409568000},"page":"2426-2431","source":"Crossref","is-referenced-by-count":2,"title":["Ventilation strategy has a major influence on remote ischaemic preconditioning in mice"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-4980","authenticated-orcid":false,"given":"Sean M.","family":"Davidson","sequence":"first","affiliation":[{"name":"The Hatter Cardiovascular Institute University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhe","family":"He","sequence":"additional","affiliation":[{"name":"The Hatter Cardiovascular Institute University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Dyson","sequence":"additional","affiliation":[{"name":"Magnus Sciences University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel I.","family":"Bromage","sequence":"additional","affiliation":[{"name":"The Hatter Cardiovascular Institute University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek M.","family":"Yellon","sequence":"additional","affiliation":[{"name":"The Hatter Cardiovascular Institute University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014494"},{"key":"e_1_2_7_3_1","first-page":"CD007160","article-title":"Oxygen therapy for acute myocardial infarction","volume":"8","author":"Cabello 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