{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:15:15Z","timestamp":1767989715550,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["YJYJ201347"],"award-info":[{"award-number":["YJYJ201347"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["YJSCI201303"],"award-info":[{"award-number":["YJSCI201303"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["YJZQN201519"],"award-info":[{"award-number":["YJZQN201519"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["201509"],"award-info":[{"award-number":["201509"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["201511"],"award-info":[{"award-number":["201511"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2015jcyjA10040"],"award-info":[{"award-number":["cstc2015jcyjA10040"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported that three point mutations in <jats:styled-content style=\"fixed-case\">SASH<\/jats:styled-content>1 and mutated <jats:styled-content style=\"fixed-case\">SASH<\/jats:styled-content>1 promote melanocyte migration in dyschromatosis universalis hereditaria (<jats:styled-content style=\"fixed-case\">DUH<\/jats:styled-content>) and a novel p53\/<jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content>\/G\u03b1s\/<jats:styled-content style=\"fixed-case\">SASH<\/jats:styled-content>1 autoregulatory positive feedback loop is regulated by <jats:styled-content style=\"fixed-case\">SASH<\/jats:styled-content>1 mutations to induce pathological hyperpigmentation phenotype. However, the underlying mechanism of molecular regulation to cause this hyperpigmentation disorder still remains unclear. In this study, we aimed to investigate the molecular mechanism undergirding hyperpigmentation in the dyschromatosis disorder. Our results revealed that <jats:styled-content style=\"fixed-case\">SASH<\/jats:styled-content>1 binds with <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>2K2 and is induced by p53\u2010<jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R signal cascade to enhance the phosphorylation level of <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>1\/2 and <jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content>. Moreover, increase in phosphorylated <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>1\/2 and <jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content> levels and melanogenesis\u2010specific molecules is induced by mutated <jats:styled-content style=\"fixed-case\">SASH<\/jats:styled-content>1 alleles. Together, our results suggest that a novel <jats:styled-content style=\"fixed-case\">SASH<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>2K2 crosstalk connects <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>1\/2\/<jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content> cascade with p53\u2010<jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R cascade to cause hyperpigmentation phenotype of <jats:styled-content style=\"fixed-case\">DUH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.13168","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T05:55:31Z","timestamp":1491458131000},"page":"2465-2480","source":"Crossref","is-referenced-by-count":25,"title":["p53 regulates <scp>ERK<\/scp>1\/2\/<scp>CREB<\/scp> cascade <i>via<\/i> a novel <scp>SASH<\/scp>1\/<scp>MAP<\/scp>2K2 crosstalk to induce hyperpigmentation"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6614-9321","authenticated-orcid":false,"given":"Ding'an","family":"Zhou","sequence":"first","affiliation":[{"name":"Clinical Research Center Affiliated Hospital of Guizhou Medical University Guiyang Guizhou China"},{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"},{"name":"Children's Hospital and Institutes of Biomedical Sciences Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongshu","family":"Kuang","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangshu","family":"Ma","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huangchao","family":"Luo","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Dujiangyan People's Hospital Cheng du Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujun","family":"Luan","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Dai","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beizhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Yongchuan Hospital Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology the First People's Hospital Chenzhou Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"He","sequence":"additional","affiliation":[{"name":"Children's Hospital and Institutes of Biomedical Sciences Fudan University Shanghai China"},{"name":"Bio\u2010X Institute Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghe","family":"Xing","sequence":"additional","affiliation":[{"name":"Children's Hospital and Institutes of Biomedical Sciences Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130203.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507595200"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00286.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01038-09"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206474"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603452"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.07.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.12.025"},{"key":"e_1_2_8_10_1","article-title":"A novel P53\/POMC\/G\u03b1s\/SASH1 auto\u2010regulatory feedback loop activates mutated SASH1 to cases pathologic hyper\u2010pigmentation","author":"Zhou D","year":"2016","journal-title":"J Cell Mol Med"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.41.24315"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2001.140205.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00652.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.045"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304838200"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.252262"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.340"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0217"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82142-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.13.s8.28.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.12.2900"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.292"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.213"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.105.4.1079"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0518fje"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12613565"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(02)02294-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.9966"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.3.827"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/34681"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2016.10.006"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33342"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1161-14.2015"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00123.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.108"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E09-05-0424"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00828-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.06.005"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.030401.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/35096009"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:53:56Z","timestamp":1696251236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jcmm.13168"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13168","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}