{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:36:14Z","timestamp":1779143774325,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500339"],"award-info":[{"award-number":["81500339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400195"],"award-info":[{"award-number":["81400195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide\u2010type diuretics hydrochlorothiazide and thiazide\u2010like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta\u2010analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol. Twelve trials were identified: five based on the comparison of indapamide <jats:italic>versus<\/jats:italic> hydrochlorothiazide and seven based on the chlorthalidone <jats:italic>versus<\/jats:italic> hydrochlorothiazide. In the meta\u2010analysis of blood pressure reduction, thiazide\u2010like diuretics seemed to further reduce systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> ([95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]; \u22125.59 [\u22125.69, \u22125.49]; <jats:italic>P<\/jats:italic> &lt; 0.001) and diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> ([95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]; \u22121.98 [\u22123.29, \u22120.66]; <jats:italic>P<\/jats:italic> = 0.003). Meanwhile, in the analysis of side effects, the incidence of hypokalemia ([95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]; 1.58 [0.80, 3.12]; <jats:italic>P<\/jats:italic> = 0.19), hyponatremia ([95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]; \u22120.14 [\u22120.57, 0.30], <jats:italic>P<\/jats:italic> = 0.54), change of blood glucose ([95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>];0.13 [\u22120.16, 0.41], <jats:italic>P<\/jats:italic> = 0.39) and total cholesterol ([95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]; 0.13 [\u22120.16, 0.41], <jats:italic>P<\/jats:italic> = 0.39) showed that there is no statistical significant differences between the two groups of drugs. In conclusion, using thiazide\u2010like diuretics is superior to thiazide\u2010type diuretics in reducing blood pressure without increasing the incidence of hypokalemia, hyponatraemia and any change of blood glucose and serum total cholesterol.<\/jats:p>","DOI":"10.1111\/jcmm.13205","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T03:18:34Z","timestamp":1497928714000},"page":"2634-2642","source":"Crossref","is-referenced-by-count":56,"title":["Comparison of thiazide\u2010like diuretics <i>versus<\/i> thiazide\u2010type diuretics: a meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Wenjing","family":"Liang","sequence":"first","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan Shandong 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