{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:21:54Z","timestamp":1768681314834,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2011\u20100030130"],"award-info":[{"award-number":["2011\u20100030130"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2016R1D1A1B03931705"],"award-info":[{"award-number":["2016R1D1A1B03931705"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The biological function of <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content> oxidase (<jats:styled-content style=\"fixed-case\">NOX<\/jats:styled-content>) is the generation of reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>, primarily arising from oxidative cell metabolism, play a major role in both chronological ageing and photoageing. <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> in extrinsic and intrinsic skin ageing may be assumed to induce the expression of matrix metalloproteinases. <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content> oxidase is closely linked with phosphatidylinositol 3\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> kinase (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K) signalling. Protein kinase C (<jats:styled-content style=\"fixed-case\">PKC<\/jats:styled-content>), a downstream molecule of <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K, is essential for superoxide generation by <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content> oxidase. However, the effect of <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NOX<\/jats:styled-content>4 in replicative\u2010aged <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s expression has not been determined. In this study, we confirmed that inhibition of the <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K signalling pathway by <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content> gene transfer abolished the <jats:styled-content style=\"fixed-case\">NOX<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 expression. Also, <jats:styled-content style=\"fixed-case\">NOX<\/jats:styled-content>\u20104 down\u2010expression of replicative\u2010aged skin cells abolished the <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 expression and <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> generation. These results suggest that increase of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 expression by replicative\u2010induced <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> is related to the change in the <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NOX<\/jats:styled-content> expression.<\/jats:p>","DOI":"10.1111\/jcmm.13220","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T07:02:49Z","timestamp":1496127769000},"page":"3113-3116","source":"Crossref","is-referenced-by-count":11,"title":["<scp>PTEN<\/scp> inhibits replicative senescence\u2010induced <scp>MMP<\/scp>\u20101 expression by regulating <scp>NOX<\/scp>4\u2010mediated <scp>ROS<\/scp> in human dermal fibroblasts"],"prefix":"10.1111","volume":"21","author":[{"given":"Eun\u2010Mi","family":"Noh","sequence":"first","affiliation":[{"name":"Center for Metabolic Function 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