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It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), which was shown to exert anti\u2010inflammation and anti\u2010oxidative capacities in other diseases. In this study, we demonstrated that <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010mitigated acute inflammation and late fibrosis caused by irradiation. <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> treatment inhibited <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21\u2010Smad3 signalling pathway and epithelial\u2013mesenchymal transition. Moreover, radiation\u2010induced imbalance of Th1\/Th2 was also alleviated by <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> treatment. Besides its free radical scavenging capacity, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> induced a huge increase of Sirt3 in culture cells and lung tissues. The level of Nrf2 and <jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>1\u03b1 in lung tissues was also elevated. In conclusion, our data showed that <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> attenuated radiation\u2010induced lung injury through inhibiting epithelial\u2013mesenchymal transition and increased the expression of Sirt3, suggesting <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> as a novel potential radioprotector for <jats:styled-content style=\"fixed-case\">RILI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.13230","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T13:35:35Z","timestamp":1497360935000},"page":"3264-3276","source":"Crossref","is-referenced-by-count":67,"title":["Polydatin alleviated radiation\u2010induced lung injury through activation of Sirt3 and inhibition of epithelial\u2013mesenchymal transition"],"prefix":"10.1111","volume":"21","author":[{"given":"Kun","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Radiation Medicine Faculty of Naval Medicine 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