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Clinical symptoms often are associated with the observed alterations in white matter in the brains of diseased children, suggesting contribution of triggered oligodendrocyte\/myelin pathology to the resulting disorders. To date, the processes initiated by perinatal asphyxia remain unclear, hampering the ability to develop preventions. To address the issue, the effects of temporal hypoxia\u2010ischaemia on survival, proliferation and the myelinating potential of oligodendrocytes were evaluated <jats:italic>ex vivo<\/jats:italic> using cultures of hippocampal organotypic slices and <jats:italic>in vivo<\/jats:italic> in rat model of perinatal asphyxia. The potential engagement of gelatinases in oligodendrocyte maturation was assessed as well. The results pointed to a significant decrease in the number of oligodendrocyte progenitor cells (<jats:styled-content style=\"fixed-case\">OPC<\/jats:styled-content>s), which is compensated for to a certain extent by the increased rate of <jats:styled-content style=\"fixed-case\">OPC<\/jats:styled-content> proliferation. Oligodendrocyte maturation seemed however to be significantly altered. An ultrastructural examination of selected brain regions performed several weeks after the insult showed however that the process of developing central nervous system myelination proceeds efficiently resulting in enwrapping the majority of axons in compact myelin. The increased angiogenesis in response to neonatal hypoxic\u2010ischaemic insult was also noticed. In conclusion, the study shows that hypoxic\u2010ischaemic episodes experienced during the most active period of nervous system development might be efficiently compensated for by the oligodendroglial cell response triggered by the insult. The main obstacle seems to be the inflammatory process modulating the local microenvironment.<\/jats:p>","DOI":"10.1111\/jcmm.13309","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:38:42Z","timestamp":1502095122000},"page":"207-222","source":"Crossref","is-referenced-by-count":33,"title":["Impact of neonatal hypoxia\u2010ischaemia on oligodendrocyte survival, maturation and myelinating potential"],"prefix":"10.1111","volume":"22","author":[{"given":"Malgorzata","family":"Ziemka\u2010Nalecz","sequence":"first","affiliation":[{"name":"NeuroRepair Department Mossakowski Medical Research Centre Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Janowska","sequence":"additional","affiliation":[{"name":"NeuroRepair Department Mossakowski Medical Research Centre Polish Academy of Sciences Warsaw 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