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However, the exact brain region and mechanism of these actions are still largely unknown. Therefore, in this study the antidepressant\u2010like effects of acute fasting on c\u2010Fos expression and BDNF levels were investigated. Consistent with our previous findings, immobility time was remarkably shortened by 9\u00a0hrs fasting in the forced swimming test. Furthermore, these antidepressant\u2010like effects of 9 fasting were inhibited by a 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>2A\/2C<\/jats:sub> receptor agonist (\u00b1)\u20101\u2010(2, 5\u2010dimethoxy\u20104\u2010iodophenyl)\u20102\u2010aminopropane hydrochloride (<jats:styled-content style=\"fixed-case\">DOI<\/jats:styled-content>), and the effect of <jats:styled-content style=\"fixed-case\">DOI<\/jats:styled-content> was blocked by pretreatment with a selective 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>2A<\/jats:sub> receptor antagonist ketanserin. Immunohistochemical study has shown that c\u2010Fos level was significantly increased by 9\u00a0hrs fasting in prefrontal cortex but not hippocampus and habenular. Fasting\u2010induced c\u2010Fos expression was further enhanced by <jats:styled-content style=\"fixed-case\">DOI<\/jats:styled-content> in prefrontal cortex, and these enhancements were inhibited by ketanserin. The increased <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels by fasting were markedly inhibited by <jats:styled-content style=\"fixed-case\">DOI<\/jats:styled-content> in frontal cortex and hippocampus, and these effects of <jats:styled-content style=\"fixed-case\">DOI<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels were also blocked by ketanserin. These findings suggest that the antidepressant\u2010like effects of acute fasting may be exerted <jats:italic>via<\/jats:italic> 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>2A<\/jats:sub> receptor and particularly sensitive to neural activity in the prefrontal cortex. Furthermore, these antidepressant\u2010like effects are also mediated by <jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> pathway in hippocampus and frontal cortex. Therefore, fasting may be potentially helpful against depression.<\/jats:p>","DOI":"10.1111\/jcmm.13310","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:32:39Z","timestamp":1502094759000},"page":"223-229","source":"Crossref","is-referenced-by-count":22,"title":["The mechanism of acute fasting\u2010induced antidepressant\u2010like effects in mice"],"prefix":"10.1111","volume":"22","author":[{"given":"Ranji","family":"Cui","sequence":"first","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetic The Second Hospital of Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Fan","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetic The Second Hospital of Jilin University Changchun 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