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Stem cell therapy offers a promising option to regenerate injured myocardium. Among the various types of stem cells, cardiosphere cells represent a mixture of intrinsic heart stem cells and supporting cells. The safety and efficacy of cardiosphere cells have been demonstrated in recent clinical trials. Cell\u2013matrix interaction plays an important role in mediating the engraftment of injected stem cells. Here, we studied the role of integrin \u03b2\u20103 in cardiosphere\u2010mediated cell therapy in a mouse model of myocardial infarction. Our results indicated that inhibiting integrin \u03b2\u20103 reduced attachment, retention and therapeutic benefits of human cardiospheres in mice with acute myocardial infarction. This suggests integrin \u03b2\u20103 plays an important role in cardiosphere\u2010mediated heart regeneration.<\/jats:p>","DOI":"10.1111\/jcmm.13325","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T04:08:38Z","timestamp":1507781318000},"page":"382-389","source":"Crossref","is-referenced-by-count":7,"title":["Integrin \u03b2\u20103 is required for the attachment, retention and therapeutic benefits of human cardiospheres in myocardial infarction"],"prefix":"10.1111","volume":"22","author":[{"given":"Suyun","family":"Liu","sequence":"first","affiliation":[{"name":"The Second Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhian","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Third Hospital of Hebei Medical University Shijiazhuang 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