{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:22:48Z","timestamp":1791595368045,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T00:00:00Z","timestamp":1512691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myeloid suppressor cells are a heterogeneous group of myeloid cells that are increased in patients with chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) inducing T cell tolerance. In this study, we found that therapy with tyrosine kinase inhibitors (<jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>) decreased the percentage of granulocytic <jats:styled-content style=\"fixed-case\">MDSC<\/jats:styled-content>, but only patients treated with dasatinib showed a significant reduction in the monocytic subset (M\u2010<jats:styled-content style=\"fixed-case\">MDSC<\/jats:styled-content>). Moreover, a positive correlation was observed between number of persistent M\u2010<jats:styled-content style=\"fixed-case\">MDSC<\/jats:styled-content> and the value of major molecular response in dasatinib\u2010treated patients. Serum and exosomes from patients with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> induced conversion of monocytes from healthy volunteers into immunosuppressive M\u2010<jats:styled-content style=\"fixed-case\">MDSC<\/jats:styled-content>, suggesting a bidirectional crosstalk between <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> cells and <jats:styled-content style=\"fixed-case\">MDSC<\/jats:styled-content>. Overall, we identified M\u2010<jats:styled-content style=\"fixed-case\">MDSC<\/jats:styled-content> as prognostic factors in patients treated with dasatinib. It might be of interest to understand whether <jats:styled-content style=\"fixed-case\">MDSC<\/jats:styled-content> may be a candidate predictive markers of relapse risk following <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> discontinuation, suggesting their potential significance as practice of precision medicine.<\/jats:p>","DOI":"10.1111\/jcmm.13326","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T05:10:53Z","timestamp":1512709853000},"page":"1070-1080","source":"Crossref","is-referenced-by-count":49,"title":["Monocytic myeloid\u2010derived suppressor cells as prognostic factor in chronic myeloid leukaemia patients treated with dasatinib"],"prefix":"10.1111","volume":"22","author":[{"given":"Cesarina","family":"Giallongo","sequence":"first","affiliation":[{"name":"Division of Hematology A.O.U. 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