{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:38:31Z","timestamp":1792201111103,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN\u2010143262"],"award-info":[{"award-number":["FDN\u2010143262"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preterm labour (PTL) is a leading cause of perinatal mortality and postnatal morbidity. Contractions of the uterine muscle (myometrium) that determine the onset of labour depend on the expression of contraction\u2010associated proteins (CAPs, <jats:italic>i.e<\/jats:italic>. connexin43) regulated by dimeric AP\u20101 transcription factors. Here, we examined subcellular (by immunoblotting) and tissue expression (by immunohistochemistry) of myometrial AP\u20101 proteins (cJUN, JUNB, JUND, cFOS, FOSB, FRA1, FRA2) throughout gestation and TL in different species (mouse, rat and human). To identify the critical AP\u20101 members associated with preterm birth, we studied their expression in mouse model of \u2018infectious\u2019 (LPS\u2010induced) and \u2018sterile\u2019 (RU486\u2010induced) PTL. We found that (1) myometrial AP\u20101 composition is preserved <jats:italic>in vivo<\/jats:italic> between different species (rodents and human) indicating that Fos\/Jun heterodimer (<jats:italic>i.e<\/jats:italic>. FRA2\/JUND) may be indispensable for labour initiation. (2) Our <jats:italic>in vivo<\/jats:italic> study using murine models of gestation shows that there is a similarity in the myometrial AP\u20101 protein composition during TL and pathological PTL of different aetiology suggesting the involvement of similar molecular machinery in the induction of labour. (3) This study is first comprehensive protein analysis of seven AP\u20101 members in human labouring <jats:italic>versus<\/jats:italic> non\u2010labouring myometrium, showing their cellular expression and tissue distribution in relation to labour status.<\/jats:p>","DOI":"10.1111\/jcmm.13335","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T10:48:41Z","timestamp":1506336521000},"page":"452-471","source":"Crossref","is-referenced-by-count":32,"title":["Differential expression of myometrial AP\u20101 proteins during gestation and labour"],"prefix":"10.1111","volume":"22","author":[{"given":"Lubna","family":"Nadeem","sequence":"first","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute Mount Sinai Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Farine","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Toronto Toronto Ontario 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lye","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute Mount Sinai Hospital Toronto Ontario Canada"},{"name":"Department of Physiology University of Toronto Toronto Ontario Canada"},{"name":"Department of Obstetrics &amp; Gynaecology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00012.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6042.965"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0140-6736(90)93247-M","article-title":"European Community collaborative study of outcome of pregnancy between 22 and 28 weeks\u2019 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