{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:48:53Z","timestamp":1762102133960,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["12\/51090\u20101"],"award-info":[{"award-number":["12\/51090\u20101"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["15\/198936\u20100"],"award-info":[{"award-number":["15\/198936\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We tested whether aerobic exercise training (<jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content>) would modulate the skeletal muscle protein quality control (<jats:styled-content style=\"fixed-case\">PQC<\/jats:styled-content>) in a model of chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) in rats. Adult Wistar rats were evaluated in four groups: control (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) or trained (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>), and 5\/6 nephrectomy sedentary (5\/6NxS) or trained (5\/6NxE). Exercised rats were submitted to treadmill exercise (60\u00a0min., five times\/wk for 2\u00a0months). We evaluated motor performance (tolerance to exercise on the treadmill and rotarod), cross\u2010sectional area (<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>), gene and protein levels related to the unfolded protein response (<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>), protein synthesis\/survive and apoptosis signalling, accumulated misfolded proteins, chymotrypsin\u2010like proteasome activity (<jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content> activity), redox balance and heat\u2010shock protein (<jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>) levels in the tibialis anterior. 5\/6NxS presented a trend towards to atrophy, with a reduction in motor performance, down\u2010regulation of protein synthesis and up\u2010regulation of apoptosis signalling; increases in <jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content> activity, misfolded proteins, <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content>78, derlin, <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>27 and <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>70 protein levels, <jats:styled-content style=\"fixed-case\">ATF<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content>78 genes; and increase in oxidative damage compared to <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> group. In 5\/6NxE, we observed a restoration in exercise tolerance, accumulated misfolded proteins, <jats:styled-content style=\"fixed-case\">UPS<\/jats:styled-content> activity, protein synthesis\/apoptosis signalling, derlin, <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>s protein levels as well as increase in <jats:styled-content style=\"fixed-case\">ATF<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content>78 genes and <jats:styled-content style=\"fixed-case\">ATF<\/jats:styled-content>6\u03b1 protein levels accompanied by a decrease in oxidative damage and increased catalase and glutathione peroxidase activities. The results suggest a disruption of <jats:styled-content style=\"fixed-case\">PQC<\/jats:styled-content> in white muscle fibres of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> rats previous to the atrophy. <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> can rescue this disruption for the <jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>, prevent accumulated misfolded proteins and reduce oxidative damage, <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>s protein levels and exercise tolerance.<\/jats:p>","DOI":"10.1111\/jcmm.13374","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T11:27:22Z","timestamp":1513682842000},"page":"1452-1463","source":"Crossref","is-referenced-by-count":13,"title":["Aerobic exercise training rescues protein quality control disruption on white skeletal muscle induced by chronic kidney disease in rats"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5155-3535","authenticated-orcid":false,"given":"Wilson Max Almeida Monteiro","family":"De Moraes","sequence":"first","affiliation":[{"name":"Biosciences Department Federal University of Sao Paulo Santos Brazil"},{"name":"Post\u2010Graduation Program on Physical Education Catholic University of Brasilia (UCB) Brasilia Federal District Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamella Ramona Moraes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Post\u2010graduation in Medicine Nove de Julho University (UNINOVE) Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie Alves","family":"da Paix\u00e3o","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Gustavo Oliveira","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Araki","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Biosciences Department Federal University of Sao Paulo Santos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea G.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Physiology and Behavior University of California Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonato","family":"Prestes","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program on Physical Education Catholic University of Brasilia (UCB) Brasilia Federal District Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Claudia","family":"Irigoyen","sequence":"additional","affiliation":[{"name":"Hypertension Unit Heart Institute University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Chakur","family":"Brum","sequence":"additional","affiliation":[{"name":"Department of Post\u2010graduation in Medicine Nove de Julho University (UNINOVE) Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Biosciences Department Federal University of Sao Paulo Santos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2015.2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/165019702317242695"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00411.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00296.2005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00695.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.473"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3182355e8c"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00236"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23282"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020993"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11630800-000000000-00000"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.03.020"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609202104"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00318.2011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-012-0204-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7053751"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00009.2016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1093\/clinchem\/29.11.1946","article-title":"Evaluation of the Coomassie Brilliant Blue G\u2010250 method for urinary protein","volume":"29","author":"Lott JA","year":"1983","journal-title":"Clin Chem"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00760.2012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.06.386"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.1.119"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80430-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12894"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041701"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1994.1357"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1319"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199702000-00001"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.07.009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118566"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010083"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18330"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.301"},{"key":"e_1_2_8_38_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/08860220801985694","article-title":"Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation","volume":"30","author":"Flisi\u2248\u00d1ski M","year":"2008","journal-title":"Ren Fail"},{"key":"e_1_2_8_39_1","first-page":"567","article-title":"Morphometric analysis of muscle fibre types in rat locomotor and postural skeletal muscles in different stages of chronic kidney disease","volume":"65","author":"Flisinski M","year":"2014","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12082"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.260"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006020131"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.009"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.5.R1539"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2006.00630.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0283"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1139\/h97-026"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:57:44Z","timestamp":1695560264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/jcmm.13374"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13374","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"type":"print","value":"1582-1838"},{"type":"electronic","value":"1582-4934"}],"subject":[],"published":{"date-parts":[[2017,12,19]]}}}