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Recently, long non\u2010coding RNAs (lncRNAs) have attracted attention because they have broad and crucial functions in regulating complex biological processes. Some studies had found that lncRNAs play vital roles in complex cardiovascular diseases. However, the function and mechanism of lncRNAs in CH have not been elucidated. In our study, to investigate the potential roles of lncRNAs in CH, the Cardiac Hypertrophy\u2010associated LncRNAs\u2010Protein coding genes Network (CHLPN) was constructed by integrating gene microarray re\u2010annotation and subpathway enrichment analyses. After performing random walking with restart in CHLPN, we predicted 21 significant risk lncRNAs, of which 7 (Kis2, 1700110K17Rik, Gm17501, E330017L17Rik, C630043F03Rik, Gm9866 and Ube4bos1) formed a close module with their co\u2010expressed protein\u2010coding genes (PCGs). We found that the module might play crucial roles in the development of CH. In particular, 44 PCGs that were co\u2010expressed with six lncRNAs were enriched in CH\u2010related biological processes and pathways. We also found that some lncRNAs participated in the competitive endogenous RNA cross\u2010talk that might be involved in CH. These results indicate that the functional lncRNAs are related to post\u2010transcriptional regulation and could shed light on a new molecular diagnostic target of CH.<\/jats:p>","DOI":"10.1111\/jcmm.13376","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T10:42:40Z","timestamp":1511174560000},"page":"892-903","source":"Crossref","is-referenced-by-count":14,"title":["Identification and analysis of a key long non\u2010coding RNAs (lncRNAs)\u2010associated module reveal functional lncRNAs in cardiac hypertrophy"],"prefix":"10.1111","volume":"22","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medical Informatics Harbin Medical University Daqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Medical Informatics Harbin Medical University Daqing 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