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Therefore, we carried out proteomic analyses of full\u2010term placentas from uncomplicated pregnancies to identify protein signatures associated with the onset of spontaneous delivery. We found quantitative associations of 10 proteins with spontaneous term birth, evident either in the basal or in the chorionic plates or in both. Additional 18 proteins were associated according to the location within placenta indicating local variations in protein amounts. Calcineurin\u2010like phosphoesterase domain\u2010containing 1 (<jats:styled-content style=\"fixed-case\">CPPED<\/jats:styled-content>1), a phosphatase previously suggested dephosphorylating <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">PKB<\/jats:styled-content>, was one of the identified proteins. <jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> revealed the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level of <jats:italic><jats:styled-content style=\"fixed-case\">CPPED<\/jats:styled-content>1<\/jats:italic> was higher in elective caesarean deliveries than in spontaneous births, while immunohistochemistry showed <jats:styled-content style=\"fixed-case\">CPPED<\/jats:styled-content>1 in cytotrophoblasts, syncytiotrophoblasts and extravillous trophoblasts. Noteworthy, phosphorylation status of <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>1 did not differ between placentas from elective caesarean and spontaneous deliveries. Additionally, analyses of samples from infants indicated that single\u2010nucleotide polymorphisms rs11643593 and rs8048866 of <jats:italic><jats:styled-content style=\"fixed-case\">CPPED<\/jats:styled-content>1<\/jats:italic> were associated with duration of term pregnancy. Finally, post\u2010transcriptional silencing of <jats:italic><jats:styled-content style=\"fixed-case\">CPPED<\/jats:styled-content>1<\/jats:italic> in cultured <jats:styled-content style=\"fixed-case\">HTR<\/jats:styled-content>8\/<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>neo cells by si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s affected gene expression in pathways associated with inflammation and blood vessel development. We postulate that functions regulated by <jats:styled-content style=\"fixed-case\">CPPED<\/jats:styled-content>1 in trophoblasts at choriodecidual interphase have a role in the induction of term labour, but it may be independent of <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>1.<\/jats:p>","DOI":"10.1111\/jcmm.13402","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:51:53Z","timestamp":1511977913000},"page":"968-981","source":"Crossref","is-referenced-by-count":17,"title":["Expression of <scp>CPPED<\/scp>1 in human trophoblasts is associated with timing of term birth"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-1552","authenticated-orcid":false,"given":"Antti M.","family":"Haapalainen","sequence":"first","affiliation":[{"name":"PEDEGO Research Unit and Medical Research Center Oulu University of Oulu Oulu Finland"},{"name":"Department of Children and Adolescents Oulu University 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