{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:25:23Z","timestamp":1776875123835,"version":"3.51.2"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671453"],"award-info":[{"award-number":["81671453"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270691"],"award-info":[{"award-number":["81270691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Penile fibrosis caused by ischemic priapism (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>) adversely affects patients\u2019 erectile function. We explored the role of lysyl oxidase (<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content>) in rat and human penes after ischemic priapism (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>) to verify the effects of anti\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> in relieving penile fibrosis and preventing erectile dysfunction caused by <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content> in rats. Seventy\u2010two rats were randomly divided into six groups: control group, control + \u03b2\u2010aminopropionitrile (<jats:styled-content style=\"fixed-case\">BAPN<\/jats:styled-content>) group, 9 hrs group, 9 hrs + <jats:styled-content style=\"fixed-case\">BAPN<\/jats:styled-content> group, 24 hrs group, and 24 hrs + <jats:styled-content style=\"fixed-case\">BAPN<\/jats:styled-content> group. \u03b2\u2010aminopropionitrile (<jats:styled-content style=\"fixed-case\">BAPN<\/jats:styled-content>), a specific inhibitor of <jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content>, was administered in the drinking water. At 1 week and 4 weeks, half of the rats in each group were randomly selected for the experiment. Compared to the control group, the erectile function of <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content> rats was significantly decreased while the expression of <jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> in the corpus cavernosum was significantly up\u2010regulated in both 9 and 24 hrs group. Proliferated fibroblasts, decreased corpus cavernosum smooth muscle cells\/collagen ratios, destroyed endothelial continuity, deposited abnormal collagen and disorganized fibers were observed in <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content> rats. The relative content of collage I and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> was not obviously different among the groups. \u03b2\u2010aminopropionitrile (<jats:styled-content style=\"fixed-case\">BAPN<\/jats:styled-content>) could effectively improve the structure and erectile function of the penis, and enhance recovery. The data in this study suggests that <jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> may play an important role in the fibrosis of corpus cavernosum after <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content> and anti\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> may be a novel target for patients suffering with <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.13411","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T10:36:53Z","timestamp":1514284613000},"page":"2018-2022","source":"Crossref","is-referenced-by-count":10,"title":["Effect of lysyl oxidase (<scp>LOX<\/scp>) on corpus cavernous fibrosis caused by ischaemic priapism"],"prefix":"10.1111","volume":"22","author":[{"given":"Liang","family":"Gao","sequence":"first","affiliation":[{"name":"The Andrology Laboratory West China Hospital Sichuan University Chengdu Sichuan 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