{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:55:43Z","timestamp":1790823343311,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771294"],"award-info":[{"award-number":["81771294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The products of erythrocyte lyses, haemoglobin (Hb) and haem, are recognized as neurotoxins and the main contributors to delayed cerebral oedema and tissue damage after intracerebral haemorrhage (<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>). Finding a means to efficiently promote absorption of the haemolytic products (Hb and haem) around the bleeding area in the brain through stimulating the function of the body's own garbage cleaning system is a novel clinical challenge and critical for functional recovery after <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>. In this review, available information of the brain injury mechanisms underlying <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> and endogenous haematoma scavenging system is provided. Meanwhile, potential intervention strategies are discussed. Intracerebral blood itself has \u2018toxic\u2019 effects beyond its volume effect after <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>. Haptoglobin\u2013Hb\u2013<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 as well as haemopexin\u2013haem\u2013<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>1 is believed to be the most important endogenous scavenging pathway which participates in blood components resolution following <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b3\u2013Nrf2 activates the aforementioned clearance pathway and then accelerates haematoma clearance. Meanwhile, the scavenger receptors as novel targets for therapeutic interventions to treat <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> are also highlighted.<\/jats:p>","DOI":"10.1111\/jcmm.13441","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T11:26:44Z","timestamp":1514287604000},"page":"768-777","source":"Crossref","is-referenced-by-count":83,"title":["Haematoma scavenging in intracerebral haemorrhage: from mechanisms to the clinic"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8977-1383","authenticated-orcid":false,"given":"Gaiqing","family":"Wang","sequence":"first","affiliation":[{"name":"The second Hospital of Shanxi Medical University Tai Yuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"The second Hospital of Shanxi Medical University Tai Yuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010gang","family":"Sun","sequence":"additional","affiliation":[{"name":"The second Hospital of Shanxi Medical University Tai Yuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Physiology Loma Linda University Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,26]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12974"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21097"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.533158"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-27"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10148"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70104-7"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.12.2580"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03268-7"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.08.004"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.659656"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2015.04.004"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23132"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.2105.2105"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342231"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2006.02.013"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.06.003"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010920"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113903"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2014010267"},{"key":"e_1_2_17_21_1","first-page":"489456","article-title":"Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease","volume":"2012","author":"Wilkinson K","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.11.010"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.10.006"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1576"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000020121.41527.5D"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600143"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.12.060"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890410033171"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0490-1"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596718"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00415"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.09.016"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1185"},{"key":"e_1_2_17_34_1","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1177\/0271678X16654494","article-title":"Low\u2010density lipoprotein receptor\u2010related protein\u20101 facilitates heme scavenging after intracerebral hemorrhage in mice","volume":"37","author":"Wang G","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81108"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011956"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2507"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4496"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24933"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.225813"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002319200"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.812537"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181659972"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12350"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200907-1047OC"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04760"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.22.12953"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-014-0228-7"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2011.00761.x"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600233"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf501373a"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033453910"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.146456"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.09.025"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(03)00369-0"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072761"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000119171.44657.45"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002254"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.07.004"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf304346r"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2014.06.007"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.181"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03790.x"},{"key":"e_1_2_17_65_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bbrc.2003.12.008","article-title":"Regulation of haptoglobin gene expression in 3T3\u2010L1 adipocytes by cytokines, catecholamines, and PPARgamma","volume":"313","author":"Nascimento CO","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(03)00150-3"},{"key":"e_1_2_17_67_1","doi-asserted-by":"crossref","first-page":"831596","DOI":"10.1155\/2013\/831596","article-title":"Vasculotoxic and Proinflammatory Effects of Plasma Heme: cell Signaling and Cytoprotective Responses","volume":"2013","author":"Belcher JD","year":"2013","journal-title":"ISRN Oxidative Med"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.478552"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130560"},{"key":"e_1_2_17_70_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7555\/JBR.28.20130105","article-title":"Class A scavenger receptor activation inhibits endoplasmic reticulum stress\u2010induced autophagy in macrophage","volume":"28","author":"Huang H","year":"2014","journal-title":"J Biomed Res"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094197"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3544"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001796"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9302-3"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.12.030"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.08.028"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-013-0272-3"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T12:14:37Z","timestamp":1695903277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,26]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jcmm.13441"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13441","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,26]]}}}