{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:09:26Z","timestamp":1791900566590,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cultivation of Guangdong College Students Scientific and Technological Innovation"},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["A2017188"],"award-info":[{"award-number":["A2017188"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Both microscopic and endoscopic transsphenoidal surgery are effective approaches for nonfunctioning pituitary adenomas. The issue on the comparison of their efficacy and safety remains inconsistent. A thorough search of the literatures (PubMed,\n                    <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                    ) were performed up to March 2017. Studies reporting outcomes of microscopic or endoscopic transsphenoidal surgery on nonfunctioning pituitary adenomas were included. A meta\u2010analysis was performed focusing on the early stage and long term outcomes. The final search yielded 19 eligible studies enrolling 3847 patients, 389 of them underwent microscopic approach and 3458 of them with endoscopic approach. As to the early stage outcomes, the rate of gross tumor resection was significantly higher in the endoscopic group than that in microscopic group (73%\n                    <jats:italic>versus<\/jats:italic>\n                    60%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Meanwhile, endoscopic approach showed priority over microscopy on postoperative hypopituitarism (63%\n                    <jats:italic>versus<\/jats:italic>\n                    65%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) and\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    leakage (3%\n                    <jats:italic>versus<\/jats:italic>\n                    7%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). For the long term outcomes, the rate of visual improvement was significant higher in the endoscopic group than that in microscopic group (77%\n                    <jats:italic>versus<\/jats:italic>\n                    50%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). However, there was no significant difference between the groups regarding the rate of permanent diabetic insipidus and meningitis. The endoscopic approach may be associated with higher rate of gross tumor movement and lower risk of postoperatively complications for treating nonfunctioning pituitary adenoma, when compared with microscopic approach. However, the confidence was shorted due to limited high quality evidence (largely randomized and controlled studies).\n                  <\/jats:p>","DOI":"10.1111\/jcmm.13445","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T16:16:55Z","timestamp":1515514615000},"page":"2023-2027","source":"Crossref","is-referenced-by-count":57,"title":["Outcomes of endoscopic and microscopic transsphenoidal surgery on non\u2010functioning pituitary adenomas: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"given":"Shi\u2010Yuan","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Neurosurgery Sun Yat\u2010sen University Cancer Center Guangzhou China"},{"name":"Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Neurosurgery Sun Yat\u2010sen University Cancer Center Guangzhou China"},{"name":"Zhongshan School of Medicine Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Neurosurgery Sun Yat\u2010sen University Cancer Center Guangzhou 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