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Recent findings have suggested an important role for mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in the pathogenesis of motor neuron diseases, including <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>. Motor neuron\u2010specific mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> dysregulation in <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> might be implicated in their selective vulnerability. In this study, we discuss recent findings regarding the consequences of <jats:styled-content style=\"fixed-case\">SMN<\/jats:styled-content> defects on mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s and their target <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s in motor neurons. Taken together, these data suggest that cell\u2010specific changes in mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s are not only involved in the <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> motor neuron phenotype but can also be used as biomarkers and therapeutic targets.<\/jats:p>","DOI":"10.1111\/jcmm.13450","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T09:46:01Z","timestamp":1511257561000},"page":"755-767","source":"Crossref","is-referenced-by-count":63,"title":["mi<scp>RNA<\/scp> in spinal muscular atrophy pathogenesis and therapy"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-9453","authenticated-orcid":false,"given":"Francesca","family":"Magri","sequence":"first","affiliation":[{"name":"Dino Ferrari Center Neuroscience Section Department of Pathophysiology and Transplantation (DEPT) Neurology Unit IRCCS Foundation Ca\u2019 Granda Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Vanoli","sequence":"additional","affiliation":[{"name":"Dino Ferrari Center Neuroscience Section Department of Pathophysiology and Transplantation (DEPT) Neurology Unit IRCCS Foundation Ca\u2019 Granda Ospedale Maggiore Policlinico University of Milan Milan Italy"},{"name":"Department of Neurological Sciences, Mental Health and Sensory Organs (NESMOS) \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Corti","sequence":"additional","affiliation":[{"name":"Dino Ferrari Center Neuroscience Section Department of Pathophysiology and Transplantation (DEPT) Neurology Unit IRCCS Foundation Ca\u2019 Granda Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.77"},{"key":"e_1_2_20_3_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-803685-3.00001-X","volume-title":"Spinal muscular atrophy. 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