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We previously had synthesized an Aza resveratrol\u2013chalcone derivative 6b, of which effectively suppressing lipopolysaccharide (LPS)\u2010induced inflammatory response in macrophages. This study aimed to investigate the potential protective effect of 6b on DCM and underlying mechanism. In H9c2 myocardial cells, 6b potently decreased high glucose (HG)\u2010induced cell fibrosis, hypertrophy and apoptosis, alleviating inflammatory response and oxidant stress. In STZ\u2010induced type 1 diabetic mice (STZ\u2010DM1), orally administration with 6b for 16 weeks significantly attenuated cardiac hypertrophy, apoptosis and fibrosis. The expression of inflammatory cytokines and oxidative stress biomarkers was also suppressed by 6b distinctly, without affecting blood glucose and body weight. The anti\u2010inflammatory and antioxidative activities of 6b were mechanistic associated with nuclear factor\u2010kappa B (NF\u2010\u03baB) nucleus entry blockage and Nrf2 activation both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. The results indicated that 6b can be a promising cardioprotective agent in treatment of DCM <jats:italic>via<\/jats:italic> inhibiting inflammation and alleviating oxidative stress. This study also validated the important role of NF\u2010\u03baB and Nrf2 taken in the pathogenesis of DCM, which could be therapeutic targets for diabetic comorbidities.<\/jats:p>","DOI":"10.1111\/jcmm.13477","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T11:42:36Z","timestamp":1515757356000},"page":"1931-1943","source":"Crossref","is-referenced-by-count":39,"title":["An Aza resveratrol\u2013chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress"],"prefix":"10.1111","volume":"22","author":[{"given":"Shengban","family":"You","sequence":"first","affiliation":[{"name":"Chemical Biology Research Center School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"Department of Cardiology the First Affiliated Hospital Wenzhou Medical University Wenzhou Zhejiang 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