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Additionally,<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>is associated with the accumulation of iron or metal ions in the brain which causes oxidative stress. Galantamine (Gal) is one of the therapeutic agents that has been approved for the treatment of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, but still saddled with numerous side effects and could not address the issue of iron accumulation in the brain. The use of metal chelators to address the iron accumulation has not been successful due to toxicity and inability to address the aggregation of the plaques. We therefore hypothesize a combinatorial antioxidant\u2013metal\u2013chelator approach by formulating a single dosage form that has the ability to prevent the formation of free radicals, plaques and accumulation of iron in the brain. This can be achieved by conjugating Gal with apo\u2010lactoferrin (ApoLf), a natural compound that has high binding affinity for iron, to form an apo\u2010lactoferrin\u2013galantamine proteo\u2010alkaloid conjugate (ApoLf\u2013Gal) as a single dosage form for<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>management. The conjugation is achieved through self\u2010assembly of ApoLf which results in encapsulation of Gal. ApoLf changes its conformational structure in the presence of iron; therefore, ApoLf\u2013Gal is proposed to deliver Gal and pick up excess iron when in contact with iron. This strategy has the potential to proffer a dual neuroprotection and neurotherapeutic interventions for the management of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.13484","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T22:12:58Z","timestamp":1517263978000},"page":"1957-1963","source":"Crossref","is-referenced-by-count":7,"title":["Hypothesis: apo\u2010lactoferrin\u2013Galantamine Proteo\u2010alkaloid Conjugate for Alzheimer's disease Intervention"],"prefix":"10.1111","volume":"22","author":[{"given":"Olufemi D.","family":"Akilo","sequence":"first","affiliation":[{"name":"Wits Advanced Drug Delivery Platform Research Unit Department of Pharmacy and Pharmacology School of Therapeutic Sciences Faculty of Health Sciences University of the Witwatersrand Johannesburg South 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