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The relationships between <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> expression and the clinicopathological characteristics and prognosis of lung adenocarcinoma patients were assessed. <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> was down\u2010regulated in <jats:styled-content style=\"fixed-case\">SPCA<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>9 and A549 cells using si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and up\u2010regulated in A549 cells using an adenoviral vector. The biological roles of <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> in cell proliferation, apoptosis, migration and invasion were determined by <jats:styled-content style=\"fixed-case\">MTT<\/jats:styled-content> and colony formation assays, flow cytometry, and transwell and wound\u2010healing assays, respectively. In addition, the regulatory roles of <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> on the expression of several epithelial\u2010mesenchymal transition (<jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>) markers were determined. Furthermore, the Rac1\/Cdc42 prenylation was detected after knockdown of <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SPCA<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>9 cells. <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> expression was significantly increased in lung adenocarcinoma tissues compared to that in adjacent normal tissues. Overexpression of <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> was correlated with large tumours, high <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stage, lymph node metastasis and poor prognosis in patients. Knockdown of <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> inhibited the migration and invasion of lung adenocarcinoma cells, but did not affect cell proliferation and apoptosis. Meanwhile, <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> inhibition significantly increased the expression of E\u2010cadherin and reduced the expression of N\u2010cadherin and vimentin in lung adenocarcinoma cells. In addition, the Rac1\/Cdc42 geranylgeranylation was reduced by <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> knockdown. Overexpression of <jats:styled-content style=\"fixed-case\">GGPPS<\/jats:styled-content> correlates with poor prognosis of lung adenocarcinoma and contributes to metastasis through regulating <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jcmm.13493","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T22:13:10Z","timestamp":1517263990000},"page":"2177-2189","source":"Crossref","is-referenced-by-count":25,"title":["Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma"],"prefix":"10.1111","volume":"22","author":[{"given":"Xiaoxia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Jinling Hospital Southern Medical University Nanjing China"},{"name":"Intensive Care Unit Inner Mongolia People's Hospital Hohhot 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