{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:45:40Z","timestamp":1760161540635,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1404802"],"award-info":[{"award-number":["U1404802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Cardiac stromal cells (CSC<\/jats:styled-content>s) can be derived from explant cultures, and a subgroup of these cells is viewed as cardiac mesenchymal stem cells due to their expression of CD<\/jats:styled-content>90. Here, we sought to determine the therapeutic potential of CD<\/jats:styled-content>90\u2010positive and CD<\/jats:styled-content>90\u2010negative CSC<\/jats:styled-content>s in a rat model of chronic myocardial infarction. We obtain CD<\/jats:styled-content>90\u2010positive and CD<\/jats:styled-content>90\u2010negative fractions of CSC<\/jats:styled-content>s from rat myocardial tissue explant cultures by magnetically activated cell sorting. In vitro<\/jats:italic>, CD<\/jats:styled-content>90\u2010negative CSC<\/jats:styled-content>s outperform CD<\/jats:styled-content>90\u2010positive CSC<\/jats:styled-content>s in tube formation and cardiomyocyte functional assays. In rats with a 30\u2010day infarct, injection of CD<\/jats:styled-content>90\u2010negative CSC<\/jats:styled-content>s augments cardiac function in the infarct in a way superior to that from CD<\/jats:styled-content>90\u2010positive CSC<\/jats:styled-content>s and unsorted CSC<\/jats:styled-content>s. Histological analysis revealed that CD<\/jats:styled-content>90\u2010negative CSC<\/jats:styled-content>s increase vascularization in the infarct. Our results suggest that CD<\/jats:styled-content>90\u2010negative CSC<\/jats:styled-content>s could be a development candidate as a new cell therapy product for chronic myocardial infarction.<\/jats:p>","DOI":"10.1111\/jcmm.13517","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T11:23:32Z","timestamp":1516188212000},"page":"1984-1991","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic benefits of CD<\/scp>90\u2010negative cardiac stromal cells in rats with a 30\u2010day chronic infarct"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-5141","authenticated-orcid":false,"given":"Deliang","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Cardiology the First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 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