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Lipoprotein\u2010associated phospholipase A2 (Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2) plays 2 diverse roles in atherosclerosis (pro\u2010inflammatory and anti\u2010inflammatory), and the association between Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross\u2010sectional study including 2012 North Chinese adults aged \u226540\u00a0years was performed in 2010\u20102011 to investigate whether Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2 mass is associated with asymptomatic cerebral artery stenosis (<jats:styled-content style=\"fixed-case\">ACAS<\/jats:styled-content>). Serum Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2 mass was determined by enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). All participants underwent transcranial Doppler (<jats:styled-content style=\"fixed-case\">TCD<\/jats:styled-content>) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (<jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>) and extracranial arterial stenosis (<jats:styled-content style=\"fixed-case\">ECAS<\/jats:styled-content>). The median serum Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2 mass of the participants was 140.74\u00a0ng\/mL (interquartile range: 131.79\u2010158.07\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>). The adjusted odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) when comparing the 4th quartile to the 1st quartile of Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2 was 1.98 (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.42\u20102.78), 1.79 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.08\u20102.94) and 1.87 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.28\u20102.73) for the occurrence of <jats:styled-content style=\"fixed-case\">ACAS<\/jats:styled-content>, asymptomatic <jats:styled-content style=\"fixed-case\">ECAS<\/jats:styled-content> and asymptomatic <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>, respectively, after controlling for vascular risk factors. These independently significant associations remained statistically significant in the male or elderly subgroups, but not in females or middle\u2010aged participants. Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2 mass is positively correlated with subclinical atherosclerosis determined by <jats:styled-content style=\"fixed-case\">ACAS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ICAS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ECAS<\/jats:styled-content> in North Chinese, particularly in male and older participants, suggesting that serum Lp\u2010<jats:styled-content style=\"fixed-case\">PLA<\/jats:styled-content>2 mass might be potential biomarker for the detection of <jats:styled-content style=\"fixed-case\">ACAS<\/jats:styled-content> in the adults.<\/jats:p>","DOI":"10.1111\/jcmm.13521","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T11:26:51Z","timestamp":1518175611000},"page":"2329-2336","source":"Crossref","is-referenced-by-count":10,"title":["Association of lipoprotein\u2010associated phospholipase A2 mass with asymptomatic 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