{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:25:45Z","timestamp":1771043145829,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["01120426"],"award-info":[{"award-number":["01120426"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313886"],"award-info":[{"award-number":["2015A030313886"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of Crohn's disease is increasing in many Asian countries, but considerable differences in genetic susceptibility have been reported between Western and Asian populations. This study aimed to fine\u2010map 23 previously reported Crohn's disease genes and identify their interactions in the Chinese population by Illumina\u2010based targeted capture sequencing. Our results showed that the genetic polymorphism A&gt;G at rs144982232 in <jats:italic>MST1<\/jats:italic> showed the most significant association (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1.78\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>; odds ratio\u00a0=\u00a04.87). <jats:italic>JAK2<\/jats:italic> rs1159782 (T&gt;C) was also strongly associated with Crohn's disease (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2.34\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>; odds ratio\u00a0=\u00a03.72). Gene\u2010gene interaction analysis revealed significant interactions between <jats:italic>MST1<\/jats:italic> and other susceptibility genes, including <jats:italic>NOD2<\/jats:italic>,<jats:italic> MUC19<\/jats:italic> and <jats:italic>ATG16L1<\/jats:italic> in contributing to Crohn's disease risk. Main genetic associations and gene\u2010gene interactions were verified using ImmunoChip data set. In conclusion, a novel susceptibility locus in <jats:italic>MST1<\/jats:italic> was identified. Our analysis suggests that <jats:italic>MST1<\/jats:italic> might interact with key susceptibility genes involved in autophagy and bacterial recognition. These findings provide insight into the genetic architecture of Crohn's disease in Chinese and may partially explain the disparity of genetic signals in Crohn's disease susceptibility across different ethnic populations by highlighting the contribution of gene\u2010gene interactions.<\/jats:p>","DOI":"10.1111\/jcmm.13530","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T05:52:36Z","timestamp":1518587556000},"page":"2368-2377","source":"Crossref","is-referenced-by-count":13,"title":["A novel susceptibility locus in <i><scp>MST<\/scp>1<\/i> and gene\u2010gene interaction network for Crohn's disease in the Chinese population"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6850-4454","authenticated-orcid":false,"given":"William K.K.","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digestive Diseases Institute of Digestive Diseases and Department of Medicine &amp; Therapeutics LKS Institute of Health Sciences CUHK Shenzhen Research Institute The Chinese University of Hong Kong Hong Kong"},{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digestive Diseases Institute of Digestive Diseases and Department of Medicine &amp; Therapeutics LKS Institute of Health Sciences CUHK Shenzhen Research Institute The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin C.Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digestive Diseases Institute of Digestive Diseases and Department of Medicine &amp; Therapeutics LKS Institute of Health Sciences CUHK Shenzhen Research Institute The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis K.L.","family":"Chan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digestive Diseases Institute of Digestive Diseases and Department of Medicine &amp; Therapeutics LKS Institute of Health Sciences CUHK Shenzhen Research Institute The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.V.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digestive Diseases Institute of Digestive Diseases and Department of Medicine &amp; Therapeutics LKS Institute of Health Sciences CUHK Shenzhen Research Institute The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph 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