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(<jats:styled-content style=\"fixed-case\">HCW<\/jats:styled-content>) has long been employed to treat hepatitis, inflammatory diseases and jaundice according to the records of \u201cThe Four Medical Tantras\u201d in China. This study was investigated to explore the protective effects of <jats:styled-content style=\"fixed-case\">HCW<\/jats:styled-content> on hepatic fibrosis and the possible mechanism in a rat model. Hepatic fibrosis was established by intragastric administration of 3\u00a0ml\/kg carbon tetrachloride (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>) twice a week for 6\u00a0weeks. <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010treated rats were received <jats:styled-content style=\"fixed-case\">HCW<\/jats:styled-content> (1 and 3\u00a0g\/kg\/d) and silymarin (0.1\u00a0g\/kg\/d) from 3 to 6\u00a0weeks. The results showed that <jats:styled-content style=\"fixed-case\">HCW<\/jats:styled-content> could significantly decrease the levels of <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ALT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LN<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PCIII<\/jats:styled-content>, Col <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106. Moreover, <jats:styled-content style=\"fixed-case\">HCW<\/jats:styled-content> could effectively inhibit collagen deposition and reduce the pathological damage. Analysis experiments finally exhibited that <jats:styled-content style=\"fixed-case\">HCW<\/jats:styled-content> was able to markedly inhibit hepatic fibrosis by modulating the expressions of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB p65, I\u03baB\u03b1, Samd3 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 proteins. Therefore, our results suggest that <jats:styled-content style=\"fixed-case\">HCW<\/jats:styled-content> has hepatoprotective activity against <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010induced hepatic fibrosis in rats by regulating the inflammatory responses.<\/jats:p>","DOI":"10.1111\/jcmm.13568","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T14:30:09Z","timestamp":1523716209000},"page":"3691-3697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hepatoprotective effect of <i>Herpetospermum caudigerum<\/i> Wall. on carbon tetrachloride\u2010induced hepatic fibrosis in rats"],"prefix":"10.1111","volume":"22","author":[{"given":"Xin","family":"Feng","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing China"},{"name":"Tibetan medicine Institute China 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