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Proton pump inhibitors (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s) have been universally accepted as first\u2010line therapy for management of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>. The potential benefits of electrolysed reduced water (<jats:styled-content style=\"fixed-case\">ERW<\/jats:styled-content>), rich in molecular hydrogen, in improving symptoms and systemic oxidative stress associated with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> was assessed. The study was performed on 84 <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients undergoing control treatment (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> + tap water) or experimental treatment (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">ERW<\/jats:styled-content>) for 3 months. These patients were subjected to the <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\u2010Health Related Quality of Life Questionnaire as well as derivatives reactive oxigen metabolites (d\u2010ROMs) test, biological antioxidant potential (<jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>) test, superoxide anion, nitric oxide and malondialdehyde assays, which were all performed as a proxy for the oxidative\/nitrosative stress and the antioxidant potential status. Spearman's correlation coefficient was used to evaluate the correlation between scores and laboratory parameters. Overall results demonstrated that an optimal oxidative balance can be restored and <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms can be reduced rapidly via the integration of <jats:styled-content style=\"fixed-case\">ERW<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients. The relative variation of heartburn and regurgitation score was significantly correlated with laboratory parameters. Thus, in the selected patients, combination treatment with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ERW<\/jats:styled-content> improves the cellular redox state leading to the improvement of the quality of life as demonstrated by the correlation analysis between laboratory parameters and <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms.<\/jats:p>","DOI":"10.1111\/jcmm.13569","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T13:16:41Z","timestamp":1520428601000},"page":"2750-2759","source":"Crossref","is-referenced-by-count":15,"title":["Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision"],"prefix":"10.1111","volume":"22","author":[{"given":"Sara","family":"Franceschelli","sequence":"first","affiliation":[{"name":"Department of Medicine and Science of Aging University \u201cG. 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