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Effective therapeutic intervention in metastatic\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    a is undermined by our poor understanding of its molecular aetiology. Defining the mechanisms underlying\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    a metastasis may lead to insights into how to decrease morbidity and mortality in this disease. Glyoxalase 1 (Glo1) is the detoxification enzyme of methylglyoxal (\n                    <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                    ), a potent precursor of advanced glycation end products (\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s). Hydroimidazolone (\n                    <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                    \u2010H1) and argpyrimidine (\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    ) are\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s originating from\n                    <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                    \u2010mediated post\u2010translational modification of proteins at arginine residues.\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    is involved in the control of epithelial to mesenchymal transition (\n                    <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                    ), a crucial determinant of cancer metastasis and invasion, whose regulation mechanisms in malignant cells are still emerging. Here, we uncover a novel mechanism linking Glo1 to the maintenance of the metastatic phenotype of\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    a cells by controlling\n                    <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                    by engaging the tumour suppressor miR\u2010101,\n                    <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                    \u2010H1\u2010\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21\/Smad signalling. Moreover, circulating levels of Glo1, miR\u2010101,\n                    <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                    \u2010H1\u2010\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21 in patients with metastatic compared with non\u2010metastatic\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    a support our in vitro results, demonstrating their clinical relevance. We suggest that Glo1, together with miR\u2010101, might be potential therapeutic targets for metastatic\n                    <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\n                    a, possibly by metformin administration.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.13581","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T06:49:30Z","timestamp":1520232570000},"page":"2865-2883","source":"Crossref","is-referenced-by-count":52,"title":["Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via\n                    <scp>EMT<\/scp>\n                    control"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-680X","authenticated-orcid":false,"given":"Cinzia","family":"Antognelli","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Riuzzi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Peirce","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo N.","family":"Talesa","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10901"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367800"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.01.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.020651"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700019200"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom5010194"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.03.026"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.01.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.061"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.2.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.10.013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(95)02054-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1333.084"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010213"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3367-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2121"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0564"},{"key":"e_1_2_8_22_1","article-title":"Do all roads lead to the Rome? 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