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Dexmedetomidine (<jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content>) and micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010140\u20105p (miR\u2010140\u20105p) have been highlighted due to its potentially significant role in the treatment of cerebral ischaemia. This study was to investigate the role by which miR\u2010140\u20105p provides cerebral protection using <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> to treat hypoxic\u2013ischaemic brain damage (<jats:styled-content style=\"fixed-case\">HIBD<\/jats:styled-content>) in neonatal rats via the Wnt\/\u03b2\u2010catenin signalling pathway. The <jats:styled-content style=\"fixed-case\">HIBD<\/jats:styled-content> rat models were established and allocated into various groups with different treatment plans, and eight <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> rats into sham group. The learning and memory ability of the rats was assessed. Apoptosis and pathological changes in the hippocampus <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 region and expressions of the related genes of the Wnt\/\u03b2\u2010catenin signalling pathway as well as the genes responsible of apoptosis were detected. Compared with the sham group, the parameters of weight, length growth, weight ratio between hemispheres, the rate of reaching standard, as well as Bcl\u20102 expressions, were all increased. Furthermore, observations of increased levels of cerebral infarction volume, total mortality rate, response times, total response duration, expressions of Wnt1, \u03b2\u2010catenin, <jats:styled-content style=\"fixed-case\">TCF<\/jats:styled-content>\u20104, E\u2010cadherin, apoptosis rate of neurons, and Bax expression were elevated. Following <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> treatment, the symptoms exhibited by <jats:styled-content style=\"fixed-case\">HIBD<\/jats:styled-content> rats were ameliorated. miR\u2010140\u20105p and si\u2010Wnt1 were noted to attenuate the progression of <jats:styled-content style=\"fixed-case\">HIBD<\/jats:styled-content>. Our study demonstrates that miR\u2010140\u20105p promotes the cerebral protective effects of <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> against <jats:styled-content style=\"fixed-case\">HIBD<\/jats:styled-content> in neonatal rats by targeting the Wnt1 gene through via the negative regulation of the Wnt\/\u03b2\u2010catenin signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.13597","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T07:29:19Z","timestamp":1521098959000},"page":"3167-3182","source":"Crossref","is-referenced-by-count":44,"title":["<i>Retracted:<\/i> Micro<scp>RNA<\/scp>\u2010140\u20105p elevates cerebral protection of dexmedetomidine against hypoxic\u2013ischaemic brain damage via the Wnt\/\u03b2\u2010catenin signalling pathway"],"prefix":"10.1111","volume":"22","author":[{"given":"Xin\u2010Rui","family":"Han","sequence":"first","affiliation":[{"name":"Key Laboratory for Biotechnology on Medicinal Plants of 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