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Although innovative therapies such as <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content> inhibitor and immune checkpoint inhibitor have gained remarkable advances, metastatic melanoma remains an incurable disease for its notorious aggressiveness. Therefore, further clarification of the underlying mechanism of melanoma pathogenesis is critical for the improvement of melanoma therapy. Ubiquitination is an important regulatory event for cancer hallmarks and melanoma development, and the deubiquitinating enzymes including ubiquitin\u2010specific peptidase (<jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>) families are greatly implicated in modulating cancer biology. Herein, we first found that the expression of the deubiquitinase <jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>4 was significantly up\u2010regulated in melanoma tissues and cell lines. Furthermore, although <jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>4 knockdown had little impact on melanoma cell proliferation, it could increase the sensitivity to <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage agent cisplatin. We subsequently showed that <jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>4 regulated cisplatin\u2010induced cell apoptosis via p53 signalling. More importantly, <jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>4 could accentuate the invasive and migratory capacity of melanoma cells by promoting epithelial\u2010mesenchymal transition. Altogether, our results demonstrate that the up\u2010regulated <jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>4 plays an oncogenic role in melanoma by simultaneously suppressing stress\u2010induced cell apoptosis and facilitating tumour metastasis.<\/jats:p>","DOI":"10.1111\/jcmm.13603","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:27:58Z","timestamp":1521116878000},"page":"2944-2954","source":"Crossref","is-referenced-by-count":39,"title":["Up\u2010regulated deubiquitinase <scp>USP<\/scp>4 plays an oncogenic role in melanoma"],"prefix":"10.1111","volume":"22","author":[{"given":"Weinan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing hospital Fourth 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