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Macrophages are critical for granuloma formation and the development of liver fibrosis during schistosomiasis. However, whether the aberrant regulation of macrophage autophagy has an effect on the development of liver immunopathology in schistosomiasis remains to be elucidated. In this study, we showed that <jats:italic>Schistosoma japonicum<\/jats:italic> (<jats:italic>S. japonicum<\/jats:italic>) egg antigen (SEA)\u2010triggered macrophage autophagy limited the development of pathology in host liver. However, engagement of IL\u20107 receptor (IL\u20107R\/CD127) on macrophages by <jats:italic>S. japonicum<\/jats:italic> infection\u2010induced IL\u20107 significantly suppressed SEA\u2010triggered macrophage autophagy, which led to an enhanced liver pathology. In addition, anti\u2010IL\u20107 neutralizing antibody or anti\u2010CD127 blocking antibody treatment increased macrophage autophagy and suppressed liver pathology. Finally, we demonstrated that IL\u20107 protects macrophage against SEA\u2010induced autophagy through activation of AMP\u2010activated protein kinase (AMPK). Our study reveals a novel role for IL\u20107 in macrophage autophagy and identifies AMPK as a novel downstream mediator of IL\u20107\u2010IL\u20107R signalling and suggests that manipulation of macrophage autophagy by targeting IL\u20107\u2010IL\u20107R signalling may have the potential to lead to improved treatment options for liver pathogenesis in schistosomiasis.<\/jats:p>","DOI":"10.1111\/jcmm.13610","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T20:28:46Z","timestamp":1521750526000},"page":"3353-3363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["IL\u20107 suppresses macrophage autophagy and promotes liver pathology in <i>Schistosoma japonicum<\/i>\u2010infected mice"],"prefix":"10.1111","volume":"22","author":[{"given":"Jifeng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology and Immunology Jiangsu Key Laboratory of Pathogen 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