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However, it remains poorly defined whether <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> participates in Hirschsprung's disease (<jats:styled-content style=\"fixed-case\">HSCR<\/jats:styled-content>). Here, we discovered that <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> increased in <jats:styled-content style=\"fixed-case\">HSCR<\/jats:styled-content> tissues. Furthermore, <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> treatment suppressed the proliferation and differentiation of neural precursor cells (<jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>s) or proliferation and migration of human 293T cells. <jats:styled-content style=\"fixed-case\">ADAR<\/jats:styled-content>2 (adenosine deaminase acting on <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>2)\u2010mediated post\u2010transcriptional adenosine\u2010to\u2010inosine <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> editing promotes cancer progression. We show that increased <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> activates <jats:styled-content style=\"fixed-case\">ADAR<\/jats:styled-content>2 and subsequently regulates the A\u2010to\u2010I <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> editing which suppresses the miR\u2010142 expression. <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> sequencing combined with <jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> suggested that <jats:styled-content style=\"fixed-case\">ADAR<\/jats:styled-content>2 restrain cell migration and proliferation via pri\u2010miR\u2010142 editing and <jats:styled-content style=\"fixed-case\">STAU<\/jats:styled-content>1 up\u2010regulation. In conclusion, the findings illustrate that <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> participates in <jats:styled-content style=\"fixed-case\">HSCR<\/jats:styled-content> through the <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ADAR<\/jats:styled-content>2\u2010miR\u2010142\u2010<jats:styled-content style=\"fixed-case\">STAU<\/jats:styled-content>1 axis.<\/jats:p>","DOI":"10.1111\/jcmm.13652","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T08:20:30Z","timestamp":1530260430000},"page":"4045-4055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lipopolysaccharide enhances <scp>ADAR<\/scp>2 which drives Hirschsprung's disease by impairing miR\u2010142\u20103p biogenesis"],"prefix":"10.1111","volume":"22","author":[{"given":"Lei","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Children's Hospital of Nanjing Medical University Nanjing China"},{"name":"Ministry of Education Key Laboratory of Modern Toxicology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary &amp; Pancreatic Surgery The Affiliated Huaian No.1 Peoples Hospital of Nanjing Medical University Huaian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of 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