{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:30:26Z","timestamp":1783647026184,"version":"3.55.0"},"reference-count":80,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science of China","doi-asserted-by":"crossref","award":["81270196"],"award-info":[{"award-number":["81270196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science of China","doi-asserted-by":"crossref","award":["81470405"],"award-info":[{"award-number":["81470405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypoxic hypoxia, including abnormally low partial pressure of inhaled oxygen, external respiratory dysfunction\u2010induced respiratory hypoxia and venous blood flow into the arterial blood, is characterized by decreased arterial oxygen partial pressure, resulting in tissue oxygen deficiency. The specific characteristics include reduced arterial oxygen partial pressure and oxygen content. Hypoxic hypoxia diseases (<jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>s) have attracted increased attention due to their high morbidity and mortality and mounting evidence showing that hypoxia\u2010induced oxidative stress, coagulation, inflammation and angiogenesis play extremely important roles in the physiological and pathological processes of <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>s\u2010related vascular endothelial injury. Interestingly, endothelial microvesicles (<jats:styled-content style=\"fixed-case\">EMV<\/jats:styled-content>s), which can be induced by hypoxia, hypoxia\u2010induced oxidative stress, coagulation and inflammation in <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>s, have emerged as key mediators of intercellular communication and cellular functions. <jats:styled-content style=\"fixed-case\">EMV<\/jats:styled-content>s shed from activated or apoptotic endothelial cells (<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>s) reflect the degree of <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>s damage, and elevated <jats:styled-content style=\"fixed-case\">EMV<\/jats:styled-content>s levels are present in several <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>s, including obstructive sleep apnoea syndrome and chronic obstructive pulmonary disease. Furthermore, <jats:styled-content style=\"fixed-case\">EMV<\/jats:styled-content>s have procoagulant, proinflammatory and angiogenic functions that affect the pathological processes of <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>s. This review summarizes the emerging roles of <jats:styled-content style=\"fixed-case\">EMV<\/jats:styled-content>s in the diagnosis, staging, treatment and clinical prognosis of <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/jcmm.13671","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T18:02:28Z","timestamp":1527616948000},"page":"3708-3718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Endothelial microvesicles in hypoxic hypoxia diseases"],"prefix":"10.1111","volume":"22","author":[{"given":"Fan","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Guangdong Medical University Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Dongfeng General Hospital Hubei University of Medicine Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Guangdong Medical University Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taihe Hospital Hubei University of Medicine Shiyan China"},{"name":"Institute of Anesthesiology Department of Anesthesiology Taihe Hospital Hubei University of Medicine Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taihe Hospital Hubei University of Medicine Shiyan China"},{"name":"Institute of Anesthesiology Department of Anesthesiology Taihe Hospital Hubei University of Medicine Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Guangdong Medical University Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030289"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430225"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17805"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447812"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5047954"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/9802026","article-title":"Endothelial microparticles act as novel diagnostic and therapeutic biomarkers of diabetes and its complications: a literature review","volume":"2016","author":"Deng F","year":"2016","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1234144"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091252"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1458OC"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.03.019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312445001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004571"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12330"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000041"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00197413"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13125"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/734509"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-008-0710-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00064-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/250476"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.12.019"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2013.784932"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2161"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S8123"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2010.6.2.89"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201012-2061OC"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201209-1697OC"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-010-9674-0"},{"key":"e_1_2_8_30_1","first-page":"8763","article-title":"Transfer of human hepatocyte growth factor reduces inflammation and prevents pulmonary arterial remodeling in monocrotaline\u2010induced pulmonary arterial hypertensive rats","volume":"7","author":"Chen J","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1727"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.137"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1512"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00117-0"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.151456"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.02.069"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2004.06.017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.05.040187.001255"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342877"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-201395"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.06.005"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0507-z"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-04-0286"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200706-840OC"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-016-0224-9"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.910551"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156940"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.11.049"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1267044"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141908"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.12.004"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3309-3"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-170273"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-014-2837-6"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430284"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0519-8"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200306-767OC"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00107408"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.081877"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/879783"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3452(08)79035-2"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445659"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12816"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0347OC"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.075"},{"key":"e_1_2_8_67_1","first-page":"1640","article-title":"Isolation and phenotypic characteristics of microparticles in acute respiratory distress syndrome","volume":"8","author":"Li H","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4985"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01172.2003"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000228791.10550.36"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.05.036"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0009-2016"},{"key":"e_1_2_8_73_1","first-page":"887","article-title":"Venous thromboembolism: pathophysiology, clinical features, and prevention","volume":"325","author":"Turpie AGG","year":"2002","journal-title":"BMJ Open"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2012.689088"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-12-1006"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-05-0280"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2010.06.005"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2223"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9802026"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22720"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31596"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.13671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.13671","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.13671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:57:38Z","timestamp":1693209458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.13671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":80,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/jcmm.13671"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.13671","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]},"assertion":[{"value":"2018-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}