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Male Wistar rats were divided into 4 groups: group C (control, n = 20) comprised animals not exposed to cigarette smoke and received standard chow; group ETS<\/jats:styled-content> (n = 20) comprised animals exposed to cigarette smoke and received standard chow; group ETS<\/jats:styled-content>100 (n = 20) received standard chow supplemented with 100 mg\/kg body weight\/d of SM<\/jats:styled-content>; and group ETS<\/jats:styled-content>250 (n = 20) received standard chow supplemented with 250 mg\/kg body weight\/d of SM<\/jats:styled-content>. The observation period was 2 months. The ETS<\/jats:styled-content> animals had higher values of left cardiac chamber diameters and of left ventricular mass index. SM<\/jats:styled-content> supplementation attenuated these changes. In addition, the myocyte cross\u2010sectional area (CSA<\/jats:styled-content>) was lower in group C compared with the ETS<\/jats:styled-content> groups; however, the ETS<\/jats:styled-content>250 group had lower values of CSA<\/jats:styled-content> compared with the ETS<\/jats:styled-content> group. The ETS<\/jats:styled-content> group also showed higher cardiac levels of lipid hydroperoxide (LH<\/jats:styled-content>) compared with group C; and, groups ETS<\/jats:styled-content>100 and ETS<\/jats:styled-content>250 had lower concentrations of LH<\/jats:styled-content> compared with the ETS<\/jats:styled-content> group. Regarding energy metabolism, SM<\/jats:styled-content> supplementation decreased glycolysis and increased the \u03b2\u2010oxidation and the oxidative phosphorylation. There were no differences in the expression of Nrf\u20102, SIRT<\/jats:styled-content>\u20101, NF<\/jats:styled-content>\u2010\u03baB, interferon\u2010gamma and interleukin 10. In conclusion, our results suggest that ETS<\/jats:styled-content> induced the cardiac remodelling process. In addition, SM<\/jats:styled-content> supplementation attenuated this process, along with oxidative stress reduction and energy metabolism modulation.<\/jats:p>","DOI":"10.1111\/jcmm.13683","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T08:34:53Z","timestamp":1527582893000},"page":"3996-4004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Spondias mombin<\/i> supplementation attenuated cardiac remodelling process induced by tobacco smoke"],"prefix":"10.1111","volume":"22","author":[{"given":"Maria Ang\u00e9lica Martins","family":"Louren\u00e7o","sequence":"first","affiliation":[{"name":"Internal Medicine Department Botucatu Medical School UNESP\u2014S\u00e3o Paulo State University Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Gobbo","family":"Braz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology 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