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Our study includes healthy controls (N\u00a0=\u00a07) and <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> pigs (N\u00a0=\u00a010). Molecular analysis showed global myocardial metabolic abnormalities, some of them related to myocardial hibernation in failing hearts, supporting the translationality of our model to study cardiac remodelling in dilated cardiomyopathy. Histological analysis showed unorganized and agglomerated collagen accumulation in the dilated ventricles and a higher percentage of fibrosis in the right (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) than in the left (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) ventricle (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.016). The Fourier Transform Infrared Spectroscopy (<jats:styled-content style=\"fixed-case\">FTIR<\/jats:styled-content>) 1st and 2nd indicators, which are markers of the myofiber\/collagen ratio, were reduced in dilated hearts, with the 1st indicator reduced by 45% and 53% in the <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>, respectively, and the 2nd indicator reduced by 25% in the <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>. The 3rd <jats:styled-content style=\"fixed-case\">FTIR<\/jats:styled-content> indicator, a marker of the carbohydrate\/lipid ratio, was up\u2010regulated in the right and left dilated ventricles but to a greater extent in the <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> (2.60\u2010fold vs 1.61\u2010fold, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.049). Differential scanning calorimetry (<jats:styled-content style=\"fixed-case\">DSC<\/jats:styled-content>) showed a depression of the freezable water melting point in <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> ventricles \u2013 indicating structural changes in the tissue architecture \u2013 and lower protein stability. Our results suggest that the 1st, 2nd and 3rd <jats:styled-content style=\"fixed-case\">FTIR<\/jats:styled-content> indicators are useful markers of cardiac remodelling. Moreover, the 2nd and 3rd <jats:styled-content style=\"fixed-case\">FITR<\/jats:styled-content> indicators, which are altered to a greater extent in the right ventricle, are associated with greater fibrosis.<\/jats:p>","DOI":"10.1111\/jcmm.13699","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T22:50:39Z","timestamp":1529448639000},"page":"4197-4208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of new biophysical markers for pathological ventricular remodelling in tachycardia\u2010induced dilated cardiomyopathy"],"prefix":"10.1111","volume":"22","author":[{"given":"Aleyda","family":"Benitez\u2010Amaro","sequence":"first","affiliation":[{"name":"Group of Lipids and Cardiovascular Pathology ICCC Program Biomedical Research Institute Sant Pau (IIB Sant Pau) Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Institute of Biomedical Research of 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